1219601-57-6

Basic information

• Product Name: 1-(p-tolylsulfonyl)triazole
• Synonyms: 1-(p-tolylsulfonyl)triazole
• CAS NO: 1219601-57-6
• Molecular Weight: 223.255
• Mol File: 1219601-57-6.mol

Chemical Properties

• CAS DataBase Reference: 1-(p-tolylsulfonyl)triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(p-tolylsulfonyl)triazole(1219601-57-6)
• EPA Substance Registry System: 1-(p-tolylsulfonyl)triazole(1219601-57-6)

Safety Data

• Hazardous Substances Data: 1219601-57-6(Hazardous Substances Data)

Usage

Type of compound

Sulfonyl triazole

Usage

Reagent in organic synthesis and medicinal chemistry

Potential as an inhibitor

Protein tyrosine phosphatases and phosphodiesterases

Applications

Studying enzymes, developing new therapeutic agents

Upstream product

• 288-36-8 1,2,3-triazole 
• 98-59-9 p-toluenesulfonyl chloride 
• 288-88-0 1,2,4-Triazole 

Downstream Products

• 118078-97-0 1-(2-pyridyl)1,2,3-triazole 
• 153653-01-1 2-(1,2,3-triazol-2-yl)pyridine 
• 1219601-40-7 C₆H₅N₅ 
• 1219601-39-4 C₆H₅N₅ 
• 30597-96-7 2-[1,2,3]triazol-1-yl-pyrimidine 
• 1219601-12-3 C₁₃H₁₀N₄ 
• 1219601-13-4 C₁₃H₁₀N₄ 
• 1312297-98-5 C₁₉H₁₉NO₃S 
• 108717-96-0 1-benzyl-4-phenyl-1H-[1,2,3]triazole 
• 1339958-80-3 2-benzyl-4-phenyl-2H-1,2,3-triazole 
• 14316-14-4 N-(2-hydroxy-ethyl)-4-methyl-benzenesulfonamide 
• 57483-27-9 N-(2-oxoethyl)-4-methylbenzenesulfonamide 

Relevant articles and documents

SUBSTITUTED ARYLMETHYLUREAS AND HETEROARYLMETHYLUREAS, ANALOGUES THEREOF, AND METHODS USING SAME

The present invention includes substituted arylmethyl ureas and heteroarylmethyl-ureas, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infections in a patient.

Organic small molecular fluorescent probe for detecting methanol and preparation method of organic small molecular fluorescent probe

The invention discloses a preparation method of an organic small molecular fluorescent probe for detecting methanol. The preparation method comprises the following steps: firstly, preparing 1-(p-toluenesulfonyl) imidazole; secondly, preparing the organic small molecular fluorescent probe: adding a proper amount of 4-bromotriphenylamine and the 1-(p-toluenesulfonyl) imidazole into a tetrahydrofuran solution, and then adding a catalyst consisting of copper sulfate pentahydrate and sodium ascorbate into the solution; protecting by nitrogen and stirring for 12 hours, extracting with dichloromethane, drying by using anhydrous magnesium sulfate, and performing rotary evaporation to obtain a crude product; performing column chromatographic separation on the crude product by using ethyl acetate and petroleum ether, wherein the volume ratio of the ethyl acetate to the petroleum ether is 1 to (10 to 20), and separating to obtain a solid, namely the organic small molecular fluorescent probe for detecting the methanol. The fluorescent probe disclosed by the invention has a high fluorescent selective response to the methanol; the fluorescence intensity is remarkably enhanced along with the prolonging of time; the organic small molecular fluorescent probe has the advantages of easiness in preparation, good chemical stability, high sensitivity and the like.

Rh-catalyzed transannulation of N-tosyl-1,2,3-triazoles with terminal alkynes

The first transannulation of 1,2,3-triazoles with terminal alkynes into pyrroles is reported. The reaction proceeds in the presence of a Rh 2(oct)4/AgOCOCF3 binary catalyst system providing a straightforward approach to 1,2,4-trisubstituted pyrroles in good to excellent yields.

One-step conversion of azine N -oxides to α-1,2,4-triazolo-, 1,2,3-triazolo, imidazolo-, and pyrazoloheteroarenes

Pyridine, quinoline, isoquinoline, azaindole, and pyrimidine N-oxides were converted to their α-triazole and α-diazole derivatives by treatment with the corresponding p-toluenesulfonylazoles and Hunigs base at elevated temperatures.

Pharmaceutical use of N-carbamoylazole derivatives

The present invention relates to use of 1-carbamoylazole derivatives as medicaments and pharmaceutical compositions containing 1-carbamoylazole derivatives as the active ingredient, based on their DPPIV inhibiting effects. The present invention provides a