121983-36-6

Basic information

• Product Name: 1,5-Dimethyl-1H-pyrazole-4-amine
• Synonyms: 1,5-Dimethyl-1H-pyrazole-4-amine;1,5-dimethyl-1H-pyrazol-4-amine(SALTDATA: 2HCl);4-AMino-1,5-diMethyl-1H-pyrazole;4-AMino-1,5-diMethylpyrazole;1,5-diMethyl-1H-pyrazol-4-aMine dihydrochloride
• CAS NO: 121983-36-6
• Molecular Formula: C₅H₉N₃
• Molecular Weight: 111.14506
• Product Categories: Amines;Bases & Related Reagents;Heterocycles;Nucleotides
• Mol File: 121983-36-6.mol

Chemical Properties

• Boiling Point: 231.5°C at 760 mmHg
• Flash Point: 93.8°C
• Appearance: /
• Density: 1.17g/cm³
• Vapor Pressure: 0.062mmHg at 25°C
• Refractive Index: 1.581
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 4.28±0.10(Predicted)
• CAS DataBase Reference: 1,5-Dimethyl-1H-pyrazole-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,5-Dimethyl-1H-pyrazole-4-amine(121983-36-6)
• EPA Substance Registry System: 1,5-Dimethyl-1H-pyrazole-4-amine(121983-36-6)

Safety Data

• Hazardous Substances Data: 121983-36-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1,5-Dimethyl-1H-pyrazole-4-amine is used as a key intermediate in the preparation of pyridine compounds, which act as focal adhesion kinase (FAK) inhibitors. FAK inhibitors are a class of drugs that target the FAK enzyme, which plays a crucial role in cell adhesion, migration, and invasion. By inhibiting FAK, these compounds have the potential to disrupt cancer cell growth and metastasis, making them valuable in the development of anticancer therapies.

InChI:InChI=1/C5H9N3/c1-4-5(6)3-7-8(4)2/h3H,6H2,1-2H3

Upstream product

• 74-88-4 methyl iodide 
• 5334-39-4 3-methyl-4-nitro-1H-pyrazole 

Downstream Products

• 1224887-26-6 2-({5-chloro-2-[(1,5-dimethyl-1H-pyrazol-4-yl)amino]-4-pyridinyl}amino)-N-methylbenzamide 
• 1453849-68-7 (S)-1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1,5-dimethyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one 
• 1215011-30-5 2,6-dichloro-N-(1,5-dimethyl-1H-pyrazol-4-yl)-4-(2-piperazin-1-yl-pyridin-4-yl)benzenesulfonamide 
• 1215011-56-5 4-bromo-2,6-dichloro-N-(1,5-dimethyl-1H-pyrazol-4-yl)benzenesulfonamide 
• 1006255-49-7 4-bromo-N-(1,5-dimethyl-1H-pyrazol-4-yl)benzenesulfonamide 
• 1201934-68-0 2-[[2-[(1,5-dimethylpyrazol-4-yl)amino]-5-(trifluoromethyl)-4-pyridyl]amino]-N-methyl-benzamide 
• 1348189-51-4 2-({5-chloro-2-[(1,5-dimethyl-1H-pyrazol-4-yl)amino]-4-pyridinyl}amino)-N-(methyloxy)benzamide 

Relevant articles and documents

Alkynyl pyrimidine or alkynyl pyridine compound as well as composition and application thereof

The invention relates to alkynyl pyrimidine or alkynyl pyridine compounds represented by a formula (I) or pharmaceutically acceptable salts, isomers, solvates, crystals or prodrugs thereof. The invention also discloses a pharmaceutical composition contain

SUBSTITUTED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF

The present disclosure relates to pyrimidine compounds of formula (I), their stereoisomers, tautomers, pharmaceutically acceptable salts, polymorphs, solvates, and hydrates thereof. The present disclosure also relates to process of preparation of these pyrimidine compounds, and to pharmaceutical compositions containing them. The compounds of the present disclosure are useful in the treatment, prevention or suppression of diseases and disorders mediated by epidermal growth factor receptor (EGFR) family kinases.