121985-97-5Relevant articles and documents
Tertiary pentyl groups enhance salen titanium catalyst for highly enantioselective trimethylsilylcyanation of aldehydes
Liang, Sidney,Bu, Xiu R.
, p. 2702 - 2704 (2007/10/03)
tert-Pentyl groups are recognized to be highly effective steric groups that can enhance enantioselectivity of salen titanium complexes when they are used in asymmetrical cyanation of aromatic aldehydes. High ee (92-97%) has been obtained with several aldehyde substrates. Compared to its tert-butyl analogue, the tert-pentyl group has been found to improve enantioselectivity and in some cases quite dramatically.
(S)-naproxen as a derivatizing agent to determine enantiomeric excess of cyanohydrins by HPLC
Solis, Aida,Luna, Hector,Perez, Herminia I.,Manjarrez, Norberto,Sanchez, Remedios,Gutierrez, Atilano
, p. 8759 - 8762 (2007/10/03)
An easy, inexpensive and accurate method to determine enantiomeric excess of cyanohydrins is described. The method consists in derivatization of cyanohydrins with (S)-naproxen chloride and the products analyzed by HPLC. The results of enantiomeric excess so determined are similar to those obtained with [Eu(hfc)3], as a chiral shift reagent, and analysis by 1H- NMR of the cyanohydrins.
Novel (R)-oxynitrilase sources for the synthesis of (R)-cyanohydrins in diisopropyl ether
Kiljunen, Eero,Kanerva, Liisa T.
, p. 1225 - 1234 (2007/10/03)
Apple, apricot, cherry and plum meal were prepared from the seeds or kernels of mature garden fruits. The preparations as well as almond meal were used as the source of (R)-oxynitrilase for the synthesis of aliphatic and aromatic cyanohydrins in diisoprop
(R)- and (S)-cyanohydrins using oxynitrilases in whole cells
Kiljunen, Eero,Kanerva, Liisa T.
, p. 1105 - 1116 (2007/10/03)
Almond meal and Sorghum bicolor shoots were used as the sources of oxynitrilases for the preparation of a number (R)- and (S)-arylcyanohydrins, respectively, from the corresponding aldehydes in diisopropyl ether. Two different in situ methods were used to introduce hydrogen cyanide into the reaction mixture. In method 1, acetone cyanohydrin decomposes enzymatically and/or chemically to hydrogen cyanide. In method 2, hydrogen cyanide freely evaporates from a solution in diisopropyl ether from one compartment of the reaction vessel and ends up to the other where it dissolves into the reaction mixture.
