122181-85-5

Basic information

• Product Name: 1H-Pyrrole-2-carboxylicacid,1-amino-,methylester(9CI)
• Synonyms: 1H-Pyrrole-2-carboxylicacid,1-amino-,methylester(9CI);1H-Pyrrole-2-carboxylicacid, 1-aMino-, Methyl ester;1-Amino-1H-pyrrole-2-carboxylic acid methyl ester;methyl 1-aminopyrrole-2-carboxylate
• CAS NO: 122181-85-5
• Molecular Formula: C₆H₈N₂O₂
• Molecular Weight: 140.1399
• Product Categories: AMINOACID;CARBOXYLICESTER
• Mol File: 122181-85-5.mol

Chemical Properties

• Melting Point: 43-44 °C
• Boiling Point: 272.3 °C at 760 mmHg
• Flash Point: 118.5 °C
• Appearance: /
• Density: 1.26 g/cm³
• Vapor Pressure: 0.00613mmHg at 25°C
• Refractive Index: 1.554
• Storage Temp.: 2-8°C(protect from light)
• PKA: -3.63±0.70(Predicted)
• CAS DataBase Reference: 1H-Pyrrole-2-carboxylicacid,1-amino-,methylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-2-carboxylicacid,1-amino-,methylester(9CI)(122181-85-5)
• EPA Substance Registry System: 1H-Pyrrole-2-carboxylicacid,1-amino-,methylester(9CI)(122181-85-5)

Safety Data

• Hazardous Substances Data: 122181-85-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1H-Pyrrole-2-carboxylic acid, 1-amino-, methyl ester (9CI) is used as a building block for the synthesis of pharmaceuticals due to its unique structure and potential biological activity. Its presence in the development of new drugs and pharmaceuticals is attributed to its ability to form complex organic molecules that can target specific biological pathways.
Used in Organic Synthesis:
In the field of organic synthesis, 1H-Pyrrole-2-carboxylic acid, 1-amino-, methyl ester (9CI) serves as a key intermediate for the creation of a variety of organic compounds. Its functional groups allow for further chemical reactions, enabling the synthesis of molecules with specific properties and applications.
Used in Material Science:
1H-Pyrrole-2-carboxylic acid, 1-amino-, methyl ester (9CI) may also find applications in material science, where its structural and chemical properties can contribute to the development of new materials with unique characteristics. Its potential use in this field is due to its ability to be integrated into polymers, composites, or other advanced materials to enhance their properties.

InChI:InChI=1/C6H8N2O2/c1-10-6(9)5-3-2-4-8(5)7/h2-4H,7H2,1H3

Upstream product

• 122181-83-3 1-phthalimido-2-carbomethoxy-1H-pyrrole 
• 1193-62-0 methyl Pyrrole-2-carboxylate 

Downstream Products

• 122181-90-2 1-((5'-carbomethoxy-4'-pentynoyl)amino)-2-carbomethoxy-1H-pyrrole 
• 122181-96-8 5'-[1-Methoxycarbonyl-meth-(E)-ylidene]-2'-oxo-2',3',4',5'-tetrahydro-[1,1']bipyrrolyl-2-carboxylic acid methyl ester 
• 1208360-01-3 1-tert-butoxycarbonylamino-1H-pyrrole-2-carboxylic acid methyl ester 
• 1232815-48-3 1-(3-benzoyl-thioureido)-1H-pyrrole-2-carboxylic acid methyl ester 
• 159326-71-3 pyrrolo<2,1-f><1,2,4>triazin-4(3H)-one 
• 1350883-07-6 methyl 1-(2,3-bis(methoxycarbonyl)guanidino)-1H-pyrrole-2-carboxylate 
• 1350883-09-8 methyl (4-chloropyrrolo[2,1-f][1,2,4]triazin-2-yl)carbamate 
• 1350882-32-4 methyl (4-(1-(1-ethoxyethyl)-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)carbamate 
• 1350883-08-7 methyl (4-oxo-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)carbamate 
• 1350882-33-5 4-(1-(1-ethoxyethyl)-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine 
• 1350882-34-6 4-(1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine 
• 159326-71-3 pyrrolo[1,2-f][1,2,4]triazin-4-ol 
• 1269667-51-7 7-bromo-4-chloropyrrolo[2,1-f][1,2,4]triazine 
• 1370007-53-6 7-bromopyrrolo[2,1-f][1,2,4]triazin-4-ol 

Relevant articles and documents

Pyrrolotriazine compounds and applications thereof

The invention belongs to the field of medical chemistry, and particularly relates to a class of lactam-based histone deacetylase inhibitors and a preparation method thereof, a pharmaceutical composition containing the histone deacetylase inhibitor, and applications of the inhibitors in drugs for preventing and/or treating diseases related to histone deacetylase activity out-of-control.

PYRROLOTRIAZINE COMPOUNDS AND METHODS OF INHIBITING TAM KINASES

Described herein are compounds, methods of making such compounds, pharmaceutical compositions, and medicaments comprising such compounds, and methods of using such compounds to treat cancer. (II), or a pharmaceutically acceptable salt thereof, wherein: R1 is pyridin-3-yl, pyridin-4-yl, pyrazol-4-yl, cyclohexyl, or 8-azabicyclo[3.2.1]oct-2- ene-3-yl, wherein R1 is optionally substituted with up to four independently selected substituents; R2 is cyclohexyl substituted with hydroxy and optionally substituted with one or two additional substituents independently selected from C1-C4 alkyl and fluoro, or is 4,5,6,7- tetrahydro-lH-indazolyl optionally substituted with one to three substituents independently selected from C1-C4 alkyl and fluoro; and R3 is -C3-C8 alkyl, -(C2-C6 alkylene)-0-(C1-C6 alkyl), C3-C6 cycloalkyl, or -(C2-C6 alkylene)-C3-C6 cycloalkyl, wherein R3 is optionally substituted with 1-5 substituents inde endentl selected from deuterium, halo, and -OH.

PYRROLOTRIAZINE INHIBITORS OF IRAK4 ACTIVITY

The present invention relates to pyrrolotriazine inhibitors of IRAK4 of formula (I) and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.

Azabicyclo derivatives, preparation methods thereof, and pharmaceutical applications thereof

The invention relates to azabicyclo derivatives, preparation methods thereof, and pharmaceutical applications thereof. Specifically, the invention discloses compounds represented by a formula (I), or pharmaceutically acceptable salts, stereoisomers, solvates or prodrugs thereof. The invention also provides preparation methods of the derivatives, and applications of the derivatives in EGFR inhibitors. The definitions of the groups in the formula are defined in the specifications.

PYRROLOTRIAZINONE DERIVATIVES AS PI3K INHIBITORS

New pyrrolotriazinone derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Phosphoinositide 3-Kinases (PI3Ks).

HETEROCYCLIC COMPOUND AS PROTEIN KINASE INHIBITOR

Provided are novel heterocyclic compounds useful as anti-cancer drugs by suppressing protein kinase activities of growth factor receptors such as c-Met, pharmaceutical compositions containing the same, and methods for using the compound.

COMPOUNDS AND METHODS FOR THEIR USE

The present invention relates to novel compounds capable of modulating the stability and/or activity of hypoxia inducible factor (HIF) by inhibiting the activity of at least one HIF hydroxylase enzyme.

PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS

The present invention provides a compound of formula (I) or a salt form thereof, wherein Q1, Q2, Q3, and Q4 are as defined herein. The compound of formula (I) has ALK and/or JAK2 inhibitory activity, and may be used to treat proliferative disorders.

Studies on the Synthesis of Phytochrome and Related Tetrapyrroles. Dihydropyrromethenones by Photochemical Rearrangement of N-Pyrrolo Enamides

Dihydropyrromethenone 67b, a potential precursor for the synthesis of phytochrome 1, has been prepared in enantiomerically pure form beginning with N-aminopyrrole 64 and the acetylenic acid 62b. The key step involved a 3,5-sigmatropic rearrangement of N-pyrrolo enamide 66b.

N-(substituted amino)pyrrole derivatives, and herbicidal compositions

This invention is to provide an N-(substituted amino)pyrrole derivative represented by the formula (I): which is used as an effective ingredient of herbicidal compositions: STR1 wherein R2, R3, R4 and R5 is independently hydrogen atom, halogen atom, C1 -C4 alkyl group, (C1 -C4 alkyl)carbonyl group, (C3 -C6 cycloalkyl) carbonyl group, (C1 -C4 haloalkyl)carbonyl group, (C3 -C5 alkenyl)carbonyl group, benzoyl group which may be substituted with 1-3 halogen atoms and/or C1 -C4 alkyl groups, N,N-[(di-C1 -C4 alkyl)amino]carbonyl group, (C1 -C4 alkoxy)carbonyl group, etc., X1 and X2 are independently hydrogen atom, halogen atom, C1 -C4 alkyl group, C1 -C4 alkoxy group, etc., and Z is nitrogen atom or CH.