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Piperazine-2-carboxylic acid methyl ester dihydrochloride is a white crystalline chemical compound that serves as a versatile intermediate in the synthesis of pharmaceuticals. It is soluble in water and ethanol, and its ability to act as a prodrug, being metabolized in the body to release the active drug, makes it a valuable component in the development of new medications.

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  • 122323-88-0 Structure
  • Basic information

    1. Product Name: Piperazine-2-carboxylic acid methyl ester dihydrochloride
    2. Synonyms: PIPERAZINE-2-CARBOXYLIC ACID METHYL ESTER DIHYDROCHLORIDE;Piperazine-2-Carboxylic Acid Methyl Ester 2HCl;[2758-98-7],C6H12N2O2, 144.09;methylester, monohydrochloride;methyl piperazine-2-carboxylate dihydrochloride;REF DUPL: Piperazine-2-carboxylic acid methyl ester dihydrochloride;2-Piperazinecarboxylic acid, Methyl ester, dihydrochloride;Methyl 2-Piperazinecarboxylate Dihydrochloride
    3. CAS NO:122323-88-0
    4. Molecular Formula: C6H12N2O2*2ClH
    5. Molecular Weight: 217.09
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 122323-88-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 223.6°Cat760mmHg
    3. Flash Point: 89°C
    4. Appearance: /
    5. Density: g/cm3
    6. Vapor Pressure: 0.0953mmHg at 25°C
    7. Refractive Index: N/A
    8. Storage Temp.: Sealed in dry,Room Temperature
    9. Solubility: N/A
    10. CAS DataBase Reference: Piperazine-2-carboxylic acid methyl ester dihydrochloride(CAS DataBase Reference)
    11. NIST Chemistry Reference: Piperazine-2-carboxylic acid methyl ester dihydrochloride(122323-88-0)
    12. EPA Substance Registry System: Piperazine-2-carboxylic acid methyl ester dihydrochloride(122323-88-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 122323-88-0(Hazardous Substances Data)

122323-88-0 Usage

Uses

Used in Pharmaceutical Synthesis:
Piperazine-2-carboxylic acid methyl ester dihydrochloride is used as a key intermediate for the production of various pharmaceuticals. Its reactivity and properties allow for the creation of a wide range of medications, contributing to the advancement of healthcare.
Used in Organic Synthesis:
As a reagent in organic synthesis, Piperazine-2-carboxylic acid methyl ester dihydrochloride is utilized for its ability to facilitate chemical reactions, leading to the formation of desired products in the synthesis of organic compounds.
Used in Drug Development:
Piperazine-2-carboxylic acid methyl ester dihydrochloride is used as a prodrug, which means it is metabolized in the body to release the active pharmaceutical agent. This application is particularly important in the development of new drugs, as it allows for the design of medications that can be more easily absorbed and utilized by the body.
Used in the Chemical Industry:
Due to its versatile properties, Piperazine-2-carboxylic acid methyl ester dihydrochloride finds applications in the chemical industry for various purposes, including the synthesis of other chemical compounds and materials. Its reactivity makes it a useful component in a range of chemical processes.

Check Digit Verification of cas no

The CAS Registry Mumber 122323-88-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,2,3,2 and 3 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 122323-88:
(8*1)+(7*2)+(6*2)+(5*3)+(4*2)+(3*3)+(2*8)+(1*8)=90
90 % 10 = 0
So 122323-88-0 is a valid CAS Registry Number.
InChI:InChI=1/C6H12N2O2.2ClH/c1-10-6(9)5-4-7-2-3-8-5;;/h5,7-8H,2-4H2,1H3;2*1H

122323-88-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name Piperazine-2-Carboxylic Acid Methyl Ester Dihydrochloride

1.2 Other means of identification

Product number -
Other names methyl piperazine-2-carboxylate,dihydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:122323-88-0 SDS

122323-88-0Relevant articles and documents

KRAS G12C INHIBITORS

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Paragraph 0247, (2020/07/25)

The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Methods of Treating Aneurysmal Dilatation, Blood Vessel Wall Weakness and Specifically Abdominal Aortic and Thoracic Aneurysm Using Matrix Metalloprotease-2 Inhibitors

-

, (2011/04/24)

The present invention provides methods of treating aneurysmal dilatation, blood vessel wall weakness, and specifically abdominal aortic aneurysm and thoracic aneurysm by inhibiting MMPs and ADAM-10. Such compounds are useful in the in vitro study of the r

SYNTHESIS AND CONVERSIONS OF PIPERAZINE-2-CARBOXYLIC ACID

Kutina, N. N.,Zhikhareva, G. P.,Anisimova, O. S.,Yakhontov, L. N.

, p. 693 - 696 (2007/10/02)

A method has been developed for the synthesis of methyl piperazinium-2-carboxylate dihydrochloride (overall yield 46percent) and piperazinium-2-carboxylic acid dihydrochloride (overall yield 36percent), from ethylene diamine through N,N'-di(trifluoroacetyl)ethylenediamine and methyl N,N'-di(trifluoroacetyl)piperazine-2-carboxylate.The N,N'-dinitroso derivatives were synthesized.

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