1223434-15-8

Basic information

• Product Name: Methyl 4-bromo-2-cyanobenzoate
• Synonyms: Methyl 4-bromo-2-cyanobenzoate
• CAS NO: 1223434-15-8
• Molecular Formula: C₉H₆BrNO₂
• Molecular Weight: 240.05344
• Mol File: 1223434-15-8.mol

Chemical Properties

• Boiling Point: 346.5±27.0 °C(Predicted)
• Appearance: /
• Density: 1.60±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Methyl 4-bromo-2-cyanobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-bromo-2-cyanobenzoate(1223434-15-8)
• EPA Substance Registry System: Methyl 4-bromo-2-cyanobenzoate(1223434-15-8)

Safety Data

• Hazardous Substances Data: 1223434-15-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 4-bromo-2-cyanobenzoate is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
Methyl 4-bromo-2-cyanobenzoate is utilized as a building block in the production of agrochemicals, contributing to the creation of compounds that can be used in agriculture for pest control and crop protection.
Used in Dye and Pigment Manufacturing:
Methyl 4-bromo-2-cyanobenzoate is employed as a key component in the manufacturing of dyes and pigments, where its unique chemical structure allows for the creation of a wide range of colors and properties.
Used in Fine Chemicals Production:
methyl 4-bromo-2-cyanobenzoate is also used in the production of other fine chemicals, where its versatility and reactivity make it a valuable asset in the synthesis of specialty chemicals for various applications.
Safety Precautions:
It is important to handle methyl 4-bromo-2-cyanobenzoate with care, as it can be toxic and may cause irritation to the skin, eyes, and respiratory system. Proper safety measures should be taken during its use and storage to minimize potential health risks.

Upstream product

• 135484-83-2 2-amino-4-bromo-benzoic acid methyl ester 
• 1093418-75-7 methyl 4-bromo-2-iodobenzoate 
• 1133123-02-0 4-bromo-2- iodobenzoic acid 

Downstream Products

• 1223434-16-9 4-bromo-2-cyanobenzoic acid 

Relevant articles and documents

RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE

Bifunctional compounds, which find utility as modulators of Rapidly Accelerated Fibrosarcoma (Raf, such as c-Raf, A-Raf, and/or B-Raf), are described herein. In particular, the hetero-bifunctional compounds of the present disclosure contain on one end a moiety that binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds Raf, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The hetero-bifunctional compounds of the present disclosure exhibit a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aberrant regulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME

The description relates to cereblon E3 ligase binding compounds, including bifunctional compounds comprising the same, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present disclosure. In particular, the description provides compounds, which contain on one end a ligand which binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. Compounds can be synthesized that exhibit a broad range of pharmacological activities consistent with the degradation/inhibition of targeted polypeptides of nearly any type.

NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE

Provided are a novel low-molecular-weight compound that suppresses production of induction type MMPs, particularly MMP-9, rather than production of hemostatic type MMP-2, as well as a prophylactic/therapeutic drug for autoimmune diseases or osteoarthritis. An amide derivative represented by the following formula (I) wherein each symbol is as defined in the specification, or a pharmacologically acceptable salt thereof.

CYCLIC AMIDE DERIVATIVE

Provided is a compound represented by formula (1) or a pharmacologically acceptable salt thereof. (In the formula, A is C6-10 arylene, etc.; R1a, R1b and R1c each independently is a hydrogen atom, a halogen atom, a C1-4 alkyl group, a C1-4 alkoxy group, etc.; R2 is an optionally substituted C6-10 aryl group, an optionally substituted 5- to 12-membered monocyclic or polycyclic heteroaryl group, an optionally substituted C7-16 aralkyl group, etc.; m is 0, etc.; n is an integer of 0 to 2.)