1093418-75-7

Usage

Uses

Used in Pharmaceutical Development:
4-Bromo-2-iodo-benzoic acid Methyl ester is utilized as a key intermediate in the synthesis of pharmaceutical compounds, particularly for the development of new drugs. Its unique structure allows for versatile chemical reactions that can lead to the creation of diverse medicinal agents.
Used in Chemical Research:
In the field of chemical research, 4-Bromo-2-iodo-benzoic acid Methyl ester serves as a valuable compound for studying the properties and reactivity of aryl halides and esters. It aids in understanding the behavior of halogens in organic synthesis and their influence on the formation of complex organic molecules.
Used in Industrial Chemical Applications:
4-Bromo-2-iodo-benzoic acid Methyl ester is employed in various industrial chemical processes, where its halide and ester functionalities contribute to the production of specialty chemicals, agrochemicals, and other chemical products. Its role in these applications is to facilitate specific chemical transformations or to enhance the properties of the end products.
Used in Academic Research:
In academic settings, 4-Bromo-2-iodo-benzoic acid Methyl ester is used as a model compound for teaching and research purposes. It helps students and researchers to understand the principles of organic chemistry, particularly the role of halogens and esters in molecular structures and their impact on chemical reactivity.
Note: The specific applications mentioned above are inferred based on the general properties of the compound and its classification. Detailed applications may vary depending on the specific context and requirements of the industry or research field. Further research and documentation are needed to provide a comprehensive list of applications for 4-Bromo-2-iodo-benzoic acid Methyl ester.

Upstream product

• 619-42-1 4-methoxycarbonylphenyl bromide 
• 135484-83-2 2-amino-4-bromo-benzoic acid methyl ester 
• 1133123-02-0 4-bromo-2- iodobenzoic acid 
• 74-88-4 methyl iodide 
• 20776-50-5 2-amino-4-bromobenzoic acid 
• 67-56-1 methanol 

Downstream Products

• 1198843-15-0 methyl 5-bromo-2-(9H-carbazol-9-yl)benzoate 
• 1223434-15-8 methyl 4-bromo-2-cyanobenzoate 
• 1223434-16-9 4-bromo-2-cyanobenzoic acid 
• 1369842-52-3 methyl 4-bromo-2-[(diethoxyphosphoryl)difluoromethyl]benzoate 
• 861605-94-9 2-phenoxy-4-bromobenzoic acid 
• 99515-51-2 phenyl 4-bromo-2-hydroxybenzoate 
• 1016313-33-9 C₁₄H₁₁BrO₃ 
• 1261438-69-0 (4-bromo-2-iodophenyl)methanol 
• 1261470-87-4 5-bromo-1-iodo-2-benzaldehyde 

Relevant academic research and scientific papers

Deprotonative cadmation of functionalized aromatics

This communication describes the deproto-metalation of a large range of aromatics including heterocycles using a newly developed lithium-cadmium base; the reaction proceeds at room temperature with an excellent chemoselectivity and efficiency, and proved to be regioselective in most cases. The Royal Society of Chemistry.

CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME

The description relates to cereblon E3 ligase binding compounds, including bifunctional compounds comprising the same, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present disclosure. In particular, the description provides compounds, which contain on one end a ligand which binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. Compounds can be synthesized that exhibit a broad range of pharmacological activities consistent with the degradation/inhibition of targeted polypeptides of nearly any type.

F- Nucleophilic-Addition-Induced [3 + 2] Annulation: Direct Access to CF3-Substituted Indenes

An efficient [3 + 2] annulation of (2,2-difluorovinyl)-2-iodoarenes and internal alkynes was developed for the synthesis of 1-(trifluoromethyl)-1H-indenes. The success of this strategy hinges upon a well-balanced process for the generation of two transient reactive species, specifically trifluoroethylsilver and alkenylpalladium intermediates, in the same molecule, as well as a smooth transmetalation step, which delicately joins together these two different metallic intermediates.

A photoredox-neutral Smiles rearrangement of 2-aryloxybenzoic acids

We report on the use of visible light photoredox catalysis for the radical Smiles rearrangement of 2-aryloxybenzoic acids to obtain aryl salicylates. The method is free of noble metals and operationally simple and the reaction can be run under mild batch or flow conditions. Being a redox neutral process, no stoichiometric oxidants or reductants are needed.

NOVEL SUBSTITUTED SPIROCYCLES

This invention relates to a compound of formula I wherein A and Cy have one of the meanings as indicated in the specification and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same and methods of using the same as agen

NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE

Provided are a novel low-molecular-weight compound that suppresses production of induction type MMPs, particularly MMP-9, rather than production of hemostatic type MMP-2, as well as a prophylactic/therapeutic drug for autoimmune diseases or osteoarthritis. An amide derivative represented by the following formula (I) wherein each symbol is as defined in the specification, or a pharmacologically acceptable salt thereof.

Deprotonative metalation of functionalized aromatics using mixed lithium-cadmium, lithium-indium, and lithium-zinc species

In situ mixtures of CdCl2TMEDA (0.5 equiv; TMEDA = N,N,N',N'-tetramethylethylenediamine) or InCl3 (0.33 equiv) with [Li(tmp)] (tmp = 2,2,6,6-tetramethylpiperidino; 1.5 or 1.3 equiv, respectively) were compared with the previously described mixture of ZnCl2-TMEDA (0.5 equiv) and [Li(tmp)] (1.5 equiv) for their ability to deprotonate anisole, benzothiazole, and pyrimidine. [(tmp)3CdLi] proved to be the best base when used in tetrahydrofuran at room temperature, as demonstrated by subsequent trapping with iodine. The Cd-Li base then proved suitable for the metalation of a large range of aromatics including benzenes bearing reactive functional groups (CONEt2, CO2Me, CN, COPh) or heavy halogens (Br, I), and heterocycles (from the furan, thiophene, pyrrole, oxazole, thiazole, pyridine, and diazine series). Fivemembered heterocycles benefiting from doubly activated positions were similarly dideprotonated at room temperature. The aromatic lithium cadmates thus obtained were involved in palladium-catalyzed cross-coupling reactions or simply quenched with acid chlorides.