122497-48-7Relevant articles and documents
Morphology change from nanotube to vesicle and monolayer/bilayer alteration by amphiphilic block polypeptides having aromatic groups at c terminal
Kim, Cheol Joo,Kurauchi, Saki,Uebayashi, Tsuguaki,Fujisaki, Ai,Kimura, Shunsaku
, p. 568 - 573 (2017)
Various amphiphilic block polypeptides having aromatic groups at the C terminal of a Leu-based hydrophobic helical block, poly(sarcosine)-b-(L-Leu-Aib)6-ethylcarbazole, poly- (sarcosine)-b-(D-Leu-Aib)6-naphthalimide, and poly(sarcosine)- b-(D-Leu-Aib)6-po
Substituted Carbazoles-A New Class of Anthelmintic Agent
Rennison, David,Gueret, Stephanie M.,Laita, Olivia,Bland, Ross J.,Sutherland, Ian A.,Boddy, Ian K.,Brimble, Margaret A.
, p. 1268 - 1276 (2016/11/25)
A series of novel carbazoles were synthesized based on structural modifications to lead carbazole 1 (EC100≤2.5M against Haemonchus contortus in vitro), which was revealed in a small molecule screening program as a potentially promising platform for the development of new anthelmintic drugs. Subsequently, analogues 19, 21, 41, 42 (EC100≤ 1.25M, all), and 39 (EC100≤0.625M) were demonstrated to exhibit enhanced in vitro anthelmintic activity over the lead structure, with compound 39 also being shown to be active in vivo against Heligmosomoides polygyrus.
HEPATITIS C VIRUS ENTRY INHIBITORS
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Page/Page column 70, (2010/11/30)
The present invention relates to the use of tricyclic diphenylamine derivative compounds for prevention and/or treatment of Hepatitis C virus (HCV) infection by inhibiting HCV entry into permissive cells.
FACILE SYNTHESIS OF NOVEL CARBAZOLES THROUGH HETEROCYCLIZATION REACTIONS AND THEIR ANTIMICROBIAL ACTIVITY
Berghot, Moged Ahmed,Badawy, Doria Saleh,Moawad, Evelin Boshra
, p. 377 - 386 (2007/10/03)
9-Ethylcarbazole binary attached to the position 3 with some heterocyclic systems such as pyrazole, pyrazolinone, pyrazoline, thiazolidinone, azetidinone, triazoline, benzimidazole, benzoxazole, benzothiazole, oxazolidinone, thiouracil and furane were synthesized.The structures of the synthesized compounds have been confirmed by analytical and spectral methods.Some of these compounds were screened to test their antimicrobial properties.
Carbazole lipoxygenase inhibiting compounds, compositions and use
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, (2008/06/13)
Compounds of the formula: STR1 wherein R1 is hydrogen, C1 to C4 alkyl, C2 to C4 alkenyl, or NR2R3, wherein R2 and R3 are independently selected from hydrogen, C1 to C4 alkyl and hydroxyl, but R2 and R3 are not simultaneously hydroxyl; X is oxygen, sulfur, CO2, or NR4, wherein R4 is hydrogen, C1 to C6 alkyl, C1 to C6 alkoyl or aroyl; A is selected from C1 to C6 alkylene and C2 to C6 alkenylene; Y is selected independently at each occurrence from hydrogen, halogen, hydroxy, cyano, nitro, halosubstituted alkyl, C1 to C12 alkyl, C2 to C12 alkenyl, C1 to C12 alkoxy, C3 to C8 cycloalkyl, aryl, aryloxy, aroyl, C1 to C12 arylalkyl, C2 to C12 arylalkenyl, C1 to C12 arylalkoxy, C1 to C12 arylthicalkoxy, and substituted derivatives of aryl, aryloxy, aroyl, C1 to C12 arylalkyl, C2 to C12 arylalkenyl, C1 to C12 arylalkoxy, or C1 to C12 arylthioalkoxy, wherein C12 alkyl, alkoxy, and halosubstituted alkyl; n is a number having the values 0-4; when n=0 then Y=hydrogen; and M is hydrogen, a pharmaceutically acceptable cation, aroyl, or C1 to C12 alkoyl. These compounds are potent inhibitors of 5- and/or 12-lipoxygenase enzymes. Also disclosed are lipoxygenase inhibiting compositions and a method of inhibiting lipoxygenase.