Design, synthesis and structure-activity relationships of 3,5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase
The synthesis and inhibitory potencies of a novel series of 3,5-diaryl-1H-pyrazoles as specific inhibitors of prokaryotic arylamine N-acetyltransferase enzymes is described. The series is based on hit compound 1 3,5-diaryl-1H-pyrazole identified from a high-throughout screen that has been carried out previously and found to inhibit the growth of Mycobacterium tuberculosis.
Fullam, Elizabeth,Talbot, James,Abuhammed, Areej,Westwood, Isaac,Davies, Stephen G.,Russell, Angela J.,Sim, Edith
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p. 2759 - 2764
(2013/06/27)
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