Design and evolution of copper apatite catalysts for N-arylation of heterocycles with chloro- and fluoroarenes
We report the preparation of recyclable heterogeneous catalysts, copper-exchanged fluorapatite, and copper-exchanged tert-butoxyapatite by incorporating basic species F-/tBuO- in apatite in situ by coprecipitation and subsequent exchange with Cu(II). These basic copper catalysts catalyzed N-arylation of imidazoles and other heterocycles with chloroarenes and electron-poor fluoroarenes in good to excellent yields. Synthesis and characterization of some of the intermediates of the catalytic cycle gave some insight into the mechanism of the very important organic transformation. The necessity of basic sites for the activation of C-Cl and C-F bonds in the N-arylation of heterocycles with haloarenes is well-established. Copyright
N-arylation of heterocycles with chloro- and fluoroarenes using resin-supported sulfonato-Cu(salen) complex
Sulfonato-Cu(salen) complex immobilized onto a Merrifield's resin was found to be an efficient catalyst for the N-arylation of heterocycles with electron-withdrawing hloro- and fluoroarenes. The reactions were carried out in the presence of an inexpensive mild base, K2CO3, and N-arylated compounds were obtained in good to excellent yields. The catalyst was recovered by simple filtration and reused for three cycles with almost consistent activity. Copyright Taylor & Francis Group, LLC.
Kantam, M. Lakshmi,Ramani,Chakrapani
p. 626 - 636
(2008/04/12)
N-arylation of heterocycles with activated chloro- and fluoroarenes using nanocrystalline copper(II) oxide
Nanocrystalline copper oxide was found to be an effective heterogeneous catalyst for the N-arylation of heterocycles with activated chloro- and fluoroarenes using potassium carbonate as base. N-Arylated products were isolated in good to excellent yields. The catalyst can be used for five cycles with almost consistent activity.
Kantam, M. Lakshmi,Yadav, Jagjit,Laha, Soumi,Sreedhar, Bojja,Jha, Shailendra
p. 1938 - 1942
(2008/09/16)
Researches on antibacterial and antifungal agents, XII1()): Analogues of bifonazole with two imidazole moieties and related azoles
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Stefancich,Silvestri,Panico,Artico,Simonetti
p. 273 - 280
(2007/10/02)
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