122648-42-4Relevant articles and documents
Synthetic Studies Targeted at the Cytotoxic 8,9-Seco-ent-kaurene Diterpenes. Concise Complementary Stereocontrolled Construction of the Bridgehead Olefin Core
Paquette, Leo A.,Ladouceur, Gaetan
, p. 4278 - 4279 (1989)
Methodology for rapid construction of the A/B aubunit of the 8,9-seco-ent-kaurenes is described that takes advantage of complementary stereocontrol in consecutive intramolecular Claisen rearrangement, allylsilane-carboxaldehyde cyclization, and oxy-Cope s
Application of the anionic oxy-cope rearrangement to stereocontrolled synthesis of the A/B subunit of cytoxic 8,9-seco-ent-kaurenes
Ladouceur,Paquette
, p. 185 - 191 (2007/10/02)
Methodology is described for expedient synthesis of the A/B framework of 8,9-seco-ent-kaurenes and for introduction of the 5-methylene-2-cyclopentenone moiety. In the first part of the study, a sequence of only six steps is necessary to convert 2-(hydroxy