39695-64-2

Upstream product

• 108-94-1 cyclohexanone 
• 109-94-4 formic acid ethyl ester 
• 6651-36-1 1-(Trimethylsilyloxy)cyclohexene 

Downstream Products

• 2257-15-0 1-cyclohexane-1,2-dione (4-methoxyphenyl)hydrazome 
• 1006707-09-0 (2,4,6-trimethylphenyl)acetic acid (2-oxocyclohexylidene)methyl ester 
• 59846-34-3 benzoic acid (2-oxocyclohexylidene)methyl ester 
• 1006707-06-7 4-methoxybenzoic acid (2-oxocyclohexylidene)methyl ester 
• 1006707-08-9 phenylacetic acid (2-oxocyclohexylidene)methyl ester 
• 1006707-10-3 naphthalene-1-carboxylic acid (2-oxocyclohexylidene)methyl ester 
• 1006707-07-8 2,4,6-trimethylbenzoic acid (2-oxocyclohexylidene)methyl ester 
• 1006707-11-4 naphthalene-2-carboxylic acid (2-oxocyclohexylidene)methyl ester 
• 118832-19-2 (R)-2-[(2S,4S)-4-Phenyl-3-(toluene-4-sulfonyl)-oxazolidin-2-yl]-cyclohexanone 
• 118832-18-1 (S)-2-[(2R,4R)-4-Phenyl-3-(toluene-4-sulfonyl)-oxazolidin-2-yl]-cyclohexanone 
• 94250-47-2 6-oxocyclohex-1-ene-1-carbaldehyde 
• 15839-23-3 2-[1-Isopropoxy-meth-(Z)-ylidene]-cyclohexanone 
• 297168-51-5 (S)-2-[(2R,4R)-4-Ethyl-3-(2,4,6-triisopropyl-benzenesulfonyl)-oxazolidin-2-yl]-cyclohexanone 
• 147727-75-1 2-<(E)-bromomethylidene>cyclohexanone 

Relevant academic research and scientific papers

Synthesis of novel precursors of Pfitzinger reaction: A facile one-pot strategy to the synthesis of quinoline carboxylic acid derivatives of pyrazolo-carbazoles and azacarbazoles

Interaction of 5-indazolyldiazonium chloride 2 with 2-hydroxymethylidene cyclohexanone 5 and N-benzyl-3-hydroxymethylidene-4-piperidone 6 under the conditions of Japp-Klingemann reaction, followed by Fischer-indolization of the resulting hydrazones, formed the 5,7,8,9-tetrahydropyrazolo[4,3-b]carbazol-6(1H) -one 9 and 9-benzyl-5,7,8,9-tetrahydropyrido[2′,3′:4,5]pyrrolo[2,3- f]indazol-6(1H)-one 10, respectively. Pfitzinger reaction of 9 and 10 with isatin in alkali afforded the corresponding quinoline carboxylic acid derivatives 12 and 13, respectively. [Figure not available: see fulltext.]

Synthesis of bicyclic salicylates by [3+3] cyclization of 1,3-bis(silyl enol ethers) with cyclic 3-(silyloxy)alk-2-en-1-ones

Bicyclic salicylates were prepared by [3+3] cyclization of 1,3-bis(silyl enol ethers) with cyclic 3-(silyloxy)alk-2-en-1-ones.

COMPOSITIONS AND METHODS FOR VIRAL INHIBITION

The present invention discloses methods and compositions for viral inhibition, particularly inhibition of HCV and SARS. The invention also provides compositions including carbazole derivatives useful for viral inhibition.

Formylation of o-silylated enolates by Vilsmeier's reagent

Reaction of trimethylsilylenol ethers and Vilsmeier's reagent leads to the corresponding regiocontrolled β-dicarbonyl compounds with high to good yields.

THERMALLY INITIATED REACTIONS OF (Z)-EPOXYHEXENYNES A FACILE PREPARATION OF 3,4-ANNULATED FURANS

An efficient and general access to 3,4-annulated 2-vinylfurans (type II) is provided by the thermally induced ring transformation of epoxyhexenynes (I).Depending on the substitution pattern the reactions proceed either by heating in solution (5a-h) or under short-time thermolysis conditions (6i, j).The results are consistent with a multistep mechanism involving 1-oxacyclohepta-3,4,6-trienes as central intermediates.

Alicyclic substituted oxazolidine-2,4-diones having hypoglycemic activity

Hypoglycemic oxazolidine-2,4-diones, substituted at the 5-position with a (C5 -C9) unsaturated monocyclic, saturated bicyclic or unsaturated bicyclic hydrocarbon radical; methods for their preparation; and method for their use in the

2-Hydroxymethylenecyclohexanones

Processes and compositions for improving, modifying or enhancing the organoleptic properties of a tobacco product which comprises adding thereto an effective amount of a 2-hydroxymethylenecyclohexanone.

A Novel Cycloaromatization Reaction. Regiocontrolled Synthesis of Substituted Methyl Salicylates

A new method of constructing six-membered rings, involving the condensation of two three-carbon units, one with two nucleophilic sites and the other containing two electrophilic sites, is reported.The regiochemistry of the reaction is controlled by the differential reactivities of these sites. 1,3-Bis(trimethylsiloxy)-1-methoxybuta-1,3-diene (1) constitutes the three-carbon fragment with two nucleophilic sites.Condensation of 1 with various equivalents of β-dicarbonyl compounds and titanium tetrachloride gave substituted methyl salicylates.The regiochemistry is controlled by the order of reactivity of the electrophilic sites, which is conjugate position of enone > ketone > monothioacetal, acetal.

5,6-Benzo analogues of prostaglandin E

Disclosed are prostaglandin analogues having the structural formula, STR1 in which: T is selected from the group consisting of carboxyl, alkoxycarbonyl or cyano; M is selected from the group consisting of carbonyl, R-hydroxymethylene or S-hydroxymethylene; L is selected from the group consisting of methylene or methine, provided L is methine only if J is methine; J is selected from the group consisting of methylene, ethylene, R-hydroxymethylene, S-hydroxymethylene or methine, provided J is methine only if L is methine; W is selected from the group consisting of --CH2 --CH-- or trans --CH=C--; T1 and T2 are attached to adjacent carbon atoms; T1 is selected from the group consisting of hydrogen or phenyl, provided T1 is phenyl only if T2 is lower alkyl; T2 is selected from the group consisting of n-pentyl or lower alkyl, provided T2 is lower alkyl only if T1 is phenyl; Or T1 and T2 are joined together to form an alkylene group of 4 or 6 carbon atoms. Also disclosed are methods for preparing such prostaglandin analogues.