cas 1227571-05-2, 4-iodo-3-methylpyridin-2(1H)-one

Articles about 1227571-05-2Total 3 be found

HETEROCYCLIC COMPOUND
A compound having an SSTR5 antagonist action and use of the compound as a medicament are provided. Specifically, a compound represented by the following formula: wherein each symbol is as defined herein, or a salt thereof, a medicament comprising the compound or a salt thereof, and use of the compound or a salt thereof as an agent the prophylaxis or treatment of diabetes mellitus are provided.
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(2015/05/05)

Pyridone methylsulfone hydroxamate LpxC inhibitors for the treatment of serious Gram-negative infections
The synthesis and biological activity of a new series of LpxC inhibitors represented by pyridone methylsulfone hydroxamate 2a is presented. Members of this series have improved solubility and free fraction when compared to compounds in the previously described biphenyl methylsulfone hydroxamate series, and they maintain superior Gram-negative antibacterial activity to comparator agents.
Montgomery, Justin I.,Brown, Matthew F.,Reilly, Usa,Price, Loren M.,Abramite, Joseph A.,Arcari, Joel,Barham, Rose,Che, Ye,Chen, Jinshan Michael,Chung, Seung Won,Collantes, Elizabeth M.,Desbonnet, Charlene,Doroski, Matthew,Doty, Jonathan,Engtrakul, Juntyma J.,Harris, Thomas M.,Huband, Michael,Knafels, John D.,Leach, Karen L.,Liu, Shenping,Marfat, Anthony,McAllister, Laura,McElroy, Eric,Menard, Carol A.,Mitton-Fry, Mark,Mullins, Lisa,Noe, Mark C.,O'Donnell, John,Oliver, Robert,Penzien, Joseph,Plummer, Mark,Shanmugasundaram, Veerabahu,Thoma, Christy,Tomaras, Andrew P.,Uccello, Daniel P.,Vaz, Alfin,Wishka, Donn G.
supporting information; experimental part
p. 1662 - 1670
(2012/04/17)

N-LINKED HYDROXAMIC ACID DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS
The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors, and more specifically their use to treat bacterial infections. Formula (I).
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Page/Page column 108

(2011/07/07)