cas 153034-80-1, 2-FLUORO-4-IODO-3-PICOLINE

Articles about 153034-80-1Total 9 be found

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HETEROCYCLIC INHIBITORS OF PTPN11
The present invention relates to compounds which may be useful as inhibitors of PTPN11 for the treatment or prevention of cancer and other PTP-mediated diseases. Disclosed herein are new compounds and compounds based on pyrazolopyrazines and their applica
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Paragraph 0412; 0413

(2018/01/04)

HYDROXYMETHYL PIPERIDINE OREXIN RECEPTOR ANTAGONISTS
The present invention is directed to hydroxymethyl piperidine compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.
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Page/Page column 35

(2016/06/28)

PYRROLIDINE OREXIN RECEPTOR ANTAGONISTS
The present invention is directed to pyrrolidine compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.
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Page/Page column 60; 61

(2016/07/05)

HETEROCYCLIC COMPOUND
A compound having an SSTR5 antagonist action and use of the compound as a medicament are provided. Specifically, a compound represented by the following formula: wherein each symbol is as defined herein, or a salt thereof, a medicament comprising the compound or a salt thereof, and use of the compound or a salt thereof as an agent the prophylaxis or treatment of diabetes mellitus are provided.
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Paragraph 0495; 0496

(2015/05/05)

Traceless solid-phase synthesis of mappicine ketone library via multiple chemoselective palladium-catalyzed reactions on benzenesulfonate linker
We report here a solid-phase synthesis of a library of mappicine ketone, a leading antiviral compound with activity against herpes viruses and human cytomegalovirus. The synthesis is based on multiple chemoselective palladium-catalyzed reactions involving
Tsukamoto, Hirokazu,Suzuki, Risako,Kondo, Yoshinori
scheme or table
p. 2005 - 2010
(2009/04/10)

A synthetic approach to 2,3,4-substituted pyridines useful as scaffolds for tripeptidomimetics
The synthesis of 2,3,4-substituted pyridine derivatives useful as scaffolds in the development of peptidomimetics is described. The use of a variety of electrophiles in a halogen-dance reaction to produce 3-alkyl-2-fluoro-4-iodo- pyridine derivatives as 'functionalized scaffolds' and the possibility to differentiate between the reactivities of the two halogen handles have been explored. Coupling of amino acid derivatives in the 4-position of the pyridine was found to proceed efficiently by conversion of iodo-pyridine to a Grignard derivative, which was allowed to react with a protected amino aldehyde. Substitution of fluorine in the 2-position of the pyridine was found to be facile with alkoxide nucleophiles, whereas amines were much less reactive.
Saitton, Stina,Kihlberg, Jan,Luthman, Kristina
p. 6113 - 6120
(2007/10/03)

Method of making asymmetric DE ring intermediates for the synthesis of camptothecin and camptothecin analogs
The present invention is directed towards new methods of making DE ring intermediates of Formula (III), STR1 wherein Y is H or halogen and R is loweralkyl, which in turn are useful in methods of making camptothecin and camptothecin analogs. The present invention also provides new compounds useful in the methods of making compounds of Formula (III).
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(2008/06/13)

Asymmetric Synthesis of a Key Camptothecin Intermediate from 2-Fluoropyridine
The DE ring camptothecin intermediate II was prepared enantioselectively in six steps from 2-fluoropyridine using a pyridine "halogen-dance" reaction.
Comins, Daniel L.,Saha, Jayanta K.
p. 7995 - 7998
(2007/10/02)

First Metalation of Aryl Iodides: Directed Ortho-Lithiation of Iodopyridines, Halogen-Dance, and Application to Synthesis
Metalation of iodopyridines was succesfully achieved by LDA at low temperature.In many cases, lithiation is ortho directed by the iodo group which subsequently ortho-migrates very fast to give stabilized iodolithiopyridines.This procedure was applied to 2
Rocca, P.,Cochennec, C.,Marsais, F.,Thomas-dit-Dumont, L.,Mallet, M.,et al.
p. 7832 - 7838
(2007/10/02)

Chemical Properties

Boiling Point: 243.507 °C at 760 mmHg
Flash Point:101.07 °C
Density: 1.893 g/cm³
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
Vapor Pressure: 0.05mmHg at 25°C
Refractive Index: 1.587
PKA: -1.53±0.18(Predicted)
PSA: 12.89000
LogP: 2.13370

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Chemical Properties

Boiling Point: 243.507 °C at 760 mmHg

Flash Point:101.07 °C

Density: 1.893 g/cm³

Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C

Vapor Pressure: 0.05mmHg at 25°C

Refractive Index: 1.587

PKA: -1.53±0.18(Predicted)

PSA: 12.89000

LogP: 2.13370

Global suppliers and manufacturers of 153034-80-1total 49 suppliers on LookChem

Article Database

153034-80-1

Articles about 153034-80-1Total 9 be found

More Articles about upstream products of 153034-80-1

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Chemical Properties

Boiling Point: 243.507 °C at 760 mmHg

Flash Point:101.07 °C

Density: 1.893 g/cm3

Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C

Vapor Pressure: 0.05mmHg at 25°C

Refractive Index: 1.587

PKA: -1.53±0.18(Predicted)

PSA: 12.89000

LogP: 2.13370

Global suppliers and manufacturers of 153034-80-1total 49 suppliers on LookChem

Density: 1.893 g/cm³