122774-00-9

Basic information

• Product Name: 2-Phenylpyrimidine-5-carbonyl chloride 97%
• Synonyms: 2-Phenylpyrimidine-5-carbonyl chloride 97%;2-PHENYLPYRIMIDINE-5-CARBONYL CHLORIDE;5-(Chlorocarbonyl)-2-phenylpyrimidine;2-Phenylpyrimidine-5-carbonylchloride97%
• CAS NO: 122774-00-9
• Molecular Formula: C₁₁H₇ClN₂O
• Molecular Weight: 218.64
• Mol File: 122774-00-9.mol

Chemical Properties

• Melting Point: 174.5-176°C
• Boiling Point: 257.5°Cat760mmHg
• Flash Point: 109.5°C
• Appearance: /
• Density: 1.304g/cm³
• Vapor Pressure: 0.015mmHg at 25°C
• Refractive Index: 1.599
• CAS DataBase Reference: 2-Phenylpyrimidine-5-carbonyl chloride 97%(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Phenylpyrimidine-5-carbonyl chloride 97%(122774-00-9)
• EPA Substance Registry System: 2-Phenylpyrimidine-5-carbonyl chloride 97%(122774-00-9)

Safety Data

• Hazard Codes: C
• Hazardous Substances Data: 122774-00-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
2-Phenylpyrimidine-5-carbonyl chloride 97% is used as an intermediate for the preparation of various pharmaceutical products. Its unique structure and reactivity make it a valuable component in the development of new drugs and therapeutic agents.
Used in Agrochemical Products:
In addition to its applications in pharmaceuticals, 2-Phenylpyrimidine-5-carbonyl chloride 97% is also utilized as an intermediate in the synthesis of agrochemical products. This allows for the development of new pesticides, herbicides, and other agricultural chemicals to improve crop yields and protect against pests.
It is important to handle and store 2-Phenylpyrimidine-5-carbonyl chloride 97% in a well-ventilated area and wear appropriate protective equipment, as it can be harmful if inhaled or comes in contact with the skin or eyes.

InChI:InChI=1/C11H7ClN2O/c12-10(15)9-6-13-11(14-7-9)8-4-2-1-3-5-8/h1-7H

Upstream product

• 64074-29-9 methyl 2-phenylpyrimidine-5-carboxylate 
• 77232-48-5 5-methyl-2-(phenyl)pyrimidine 
• 1670-14-0 benzamidine monohydrochloride 
• 85386-14-7 2-phenylpyrimidine-5-carboxylic acid ethyl ester 
• 122773-97-1 2-phenylpyrimidine-5-carboxylic acid 

Downstream Products

• 1217902-54-9 N-(2-oxo-2-phenylethyl)-2-phenylpyrimidine-5-carboxamide 
• 1068969-31-2 [N'-(2-phenyl-pyrimidine-5-carbonyl)-hydrazino]-acetamide 
• 1068969-71-0 2-phenyl-pyrimidine-5-carboxylic acid (5-fluoro-indol-1-yl)-amide 
• 1068969-30-1 [N'-(2-phenyl-pyrimidine-5-carbonyl)-hydrazino]-acetic acid ethyl ester 
• 1068968-22-8 3-oxo-4-[(2-phenyl-pyrimidine-5-carbonyl)-amino]-piperazine-1-carboxylic acid benzyl ester 
• 1068972-13-3 2-phenyl-pyrimidine-5-carboxylic acid (indol-1-yl)-amide 
• 1068969-33-4 2-phenyl-pyrimidine-5-carboxylic acid (2,3-dihydro-indol-1-yl)-amide 
• 85386-15-8 2-phenylpyrimidine-5-carbonitrile 
• 85386-14-7 2-phenylpyrimidine-5-carboxylic acid ethyl ester 
• 122773-96-0 2-phenylpyrimidine-5-carboxylic acid amide 

Relevant articles and documents

MULTIHETEROARYL COMPOUNDS AS INHIBITORS OF H-PGDS AND THEIR USE FOR TREATING PROSTAGLANDIN D2 MEDIATED DISEASES

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PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS

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Inhibitors of NF-kappaB and AP-1 gene expression: SAR studies on the pyrimidine portion of 2-chloro-4-trifluoromethylpyrimidine-5-[N-(3', 5'-bis(trifluoromethyl)phenyl)carboxamide].

We investigated the structure-activity relationship studies of N-[3, 5-bis(trifluoromethyl)phenyl][2-chloro-4-(trifluoromethyl)pyrimidin-5 -yl]carboxamide (1), an inhibitor of transcription mediated by both NF-kappaB and AP-1 transcription factors, with the goal of improving its potential oral bioavailability. Compounds were examined for cell-based activity, were fit to Lipinski's rule of 5, and were examined for potential gastrointestinal permeability using the intestinal epithelial cell line, Caco-2. Selected groups were substituted at the 2-, 4-, and 5-positions of the pyrimidine ring using solution-phase combinatorial methodology. The introduction of a fluorine in the place of 2-chlorine of 1 resulted in a compound with comparable activity. However, other substitutions at the 2-position resulted in a loss of activity. The trifluoromethyl group at the 4-position could be replaced with a methyl, ethyl, chlorine, or phenyl without a substantial loss of activity. The carboxamide group at the 5-position is critical for activity. If it was moved to the 6-position, the activity was lost. The 2-methyl analogue of 1 (81) showed comparable in vitro activity and improved Caco-2 permeability compared to 1.

Pyrimidine carboxamides and related compounds and methods for treating inflammatory conditions

Compounds having utility as antinflammatory agents in general and, more specifically, for the prevention and/or treatment of immunoinflammatory and autoimmune diseases are disclosed. The compounds are pyrimidine- or pyrazine-containing compounds and, in one embodiment, are carboxyamides of the same. Methods are also disclosed for preventing and/or treating inflammatory conditions by administering to an animal in need thereof an effective amount of a compound of this invention, preferably in the form of a pharmaceutical composition.

SYNTHESIS OF 2,5'-BIPYRIMIDINES FROM SUBSTITUTED 5-CYANOPYRIMIDINES

The Pinner method was applied to substituted 5-cyanopyrimidines to obtain 5-aminopyrimidines, which were condensed with acrolein derivatives to synthesize compounds that contain a 2,5-bipyrimidine fragment.