77232-48-5

Basic information

• Product Name: 5-METHYL-2-PHENYLPYRIMIDINE
• Synonyms: 5-METHYL-2-PHENYLPYRIMIDINE
• CAS NO: 77232-48-5
• Molecular Formula: C₁₁H₁₀N₂
• Molecular Weight: 170.21
• Mol File: 77232-48-5.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-METHYL-2-PHENYLPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHYL-2-PHENYLPYRIMIDINE(77232-48-5)
• EPA Substance Registry System: 5-METHYL-2-PHENYLPYRIMIDINE(77232-48-5)

Safety Data

• Hazardous Substances Data: 77232-48-5(Hazardous Substances Data)

Upstream product

• 68906-00-3 2-phenyl-5-nitropyrimidine 
• 6407-34-7 methyl-1 ethylideneamine 
• 108805-57-8 N,N,N',N'-tetramethyl-2-methyl-malondialdehyde diimine hydrochloride 
• 100-47-0 benzonitrile 
• 22536-61-4 2-chloro-5-methylpyrimidine 
• 98-80-6 phenylboronic acid 
• 42588-57-8 3-ethoxymethacrolein 
• 74222-83-6 benzamidine hydrochloride hydrate 
• 920518-65-6 3-dimethyl-amino-2-methylpropenal 
• 95804-09-4 N-Triphenylphosphoranyliden-benzamidin 
• 104322-41-0 (+)-(2R)-benzyloxy-2,5-dihydrofuran-4-carboxaldehyde 
• 1670-14-0 benzamidine monohydrochloride 
• 960-16-7 tributylphenylstannane 

Downstream Products

• 1637587-29-1 2-(5-methylpyrimidin-2-yl)benzonitrile 
• 122773-96-0 2-phenylpyrimidine-5-carboxylic acid amide 
• 122774-00-9 2-phenylpyrimidine-5-carbonyl chloride 
• 85386-15-8 2-phenylpyrimidine-5-carbonitrile 
• 85386-14-7 2-phenylpyrimidine-5-carboxylic acid ethyl ester 
• 77232-11-2 <4-(5'-Methylpyrimidin-2'-yl)phenylmethyl>phosphonsaeure-diaethylester 
• 77232-36-1 2-(p-Brommethyl-phenyl)-5-methyl-pyrimidin 
• 122773-97-1 2-phenylpyrimidine-5-carboxylic acid 

Relevant articles and documents

Ruthenium-Catalyzed meta-Selective C?H Mono- and Difluoromethylation of Arenes through ortho-Metalation Strategy

The first example for the ruthenium-catalyzed ligand-directed meta-selective C?H mono- and difluoromethylation is developed, affording a variety of new meta-mono- and difluoromethylated 2-phenylpyridines, 2-phenylpyrimidines, and 1-phenylpyrazoles in moderate-to-good yields. This new transformation exhibits broad substrate scope, good functional group tolerance, and high efficiency, and offers a practical approach to synthesize mono- and difluoromethylated arenes. Mechanistic studies indicate that a reaction pathway involving palladium-initiated radical species is involved in the catalytic cycle. The new dual catalytic system consisting of compatible ruthenium(II) and palladium(0) complexes enables the key processes of C?H activation and mono-/difluoromethyl-radical formation to occur and achieves the meta-selective functionalization efficiently. In addition, the present protocol can also be extended to non-fluoromethylation.

Copper-catalyzed, oxidative sp2 C-H cyanation: Facile synthesis of aromatic carbonitriles

Cu(OAc)2-catalyzed regioselective oxidative C-H cyanation of two different types of aromatics was described, providing facile access to functionalized heterocycles in good yields. Control experiments suggest the copper chelation-assisted oxidative C-H activation mechanism. ARKAT-USA, Inc.

New transformation of 2-substituted 5-nitropyrimidines by the action of the enamine form of N-methylacetone imine [4]

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