- Homocamptothecin compound and synthesis method thereof
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The invention relates to camptothecin, in particular relates to homocamptothecin compounds and a synthesis method thereof, and mainly solves the technical problems of poor solubility and bioavailability of homocamptothecin in the prior art. Structural formulas of the homocamptothecin compounds are as shown in I and II, and the homocamptothecin compounds comprise racemic compounds and (S)-and (R)-stereisomers corresponding to the racemic compounds. The invention specifically relates to derivation of 10-hydroxyl homocamptothecin compound, the 10-hydroxyl homocamptothecin is used as a mother nucleus for synthesis of a series of homocamptothecin ester and amide compounds. The invention provides a new synthetic route, and according to the path, a full synthesis ring enlargement method is not needed, and protection and deprotection are not needed.
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Paragraph 0026; 0027
(2017/08/27)
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