122842-26-6

Basic information

• Product Name: indolizino[1,2-b]quinoline-7-acetate, alpha-ethyl-9,11-dihydro-alpha,2-dihydroxy-8-(hydroxymethyl)-9-oxo-, sodium salt, (alphaS)- (1:2)
• CAS NO: 122842-26-6
• Molecular Formula: C₂₀H₁₇N₂Na₂O₆
• Molecular Weight: 427.3378
• Mol File: 122842-26-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 838.2°C at 760 mmHg
• Flash Point: 460.7°C
• Vapor Pressure: 8.1E-30mmHg at 25°C
• CAS DataBase Reference: indolizino[1,2-b]quinoline-7-acetate, alpha-ethyl-9,11-dihydro-alpha,2-dihydroxy-8-(hydroxymethyl)-9-oxo-, sodium salt, (alphaS)- (1:2)(CAS DataBase Reference)
• NIST Chemistry Reference: indolizino[1,2-b]quinoline-7-acetate, alpha-ethyl-9,11-dihydro-alpha,2-dihydroxy-8-(hydroxymethyl)-9-oxo-, sodium salt, (alphaS)- (1:2)(122842-26-6)
• EPA Substance Registry System: indolizino[1,2-b]quinoline-7-acetate, alpha-ethyl-9,11-dihydro-alpha,2-dihydroxy-8-(hydroxymethyl)-9-oxo-, sodium salt, (alphaS)- (1:2)(122842-26-6)

Safety Data

• Hazardous Substances Data: 122842-26-6(Hazardous Substances Data)

Upstream product

• 19685-09-7 (S)-10-hydroxycamptothecin 

Relevant articles and documents

Homocamptothecin compound and synthesis method thereof

The invention relates to camptothecin, in particular relates to homocamptothecin compounds and a synthesis method thereof, and mainly solves the technical problems of poor solubility and bioavailability of homocamptothecin in the prior art. Structural formulas of the homocamptothecin compounds are as shown in I and II, and the homocamptothecin compounds comprise racemic compounds and (S)-and (R)-stereisomers corresponding to the racemic compounds. The invention specifically relates to derivation of 10-hydroxyl homocamptothecin compound, the 10-hydroxyl homocamptothecin is used as a mother nucleus for synthesis of a series of homocamptothecin ester and amide compounds. The invention provides a new synthetic route, and according to the path, a full synthesis ring enlargement method is not needed, and protection and deprotection are not needed.