cas 122891-92-3, 1-BENZENESULFONYL-PIPERIDINE-4-CARBOXYLIC ACID | Articles data ｜lookchem

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122891-92-3

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CASPASE INHIBITOR AND PHARMACEUTICAL COMPOSITION, USE AND THERAPEUTIC METHOD THEREOF
Disclosed are a class of compounds as a caspase inhibitor, and in particular the compound as shown in formula (I) or a pharmaceutically acceptable salt thereof, and the use of the compound in treating caspase-related diseases.
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Paragraph 0554; 0556

(2019/04/05)

Alkyl piperidine and piperazine hydroxamic acids as HDAC inhibitors
We report here the strategy used in our research group to find a new class of histone deacetylase (HDAC) inhibitors. A series of N-substituted 4-alkylpiperazine and 4-alkylpiperidine hydroxamic acids, corresponding to the basic structure of HDAC inhibitors (zinc binding moiety-linker-capping group) has been designed, prepared, and tested for HDAC inhibition. Linker length and aromatic capping group connection were systematically varied to find the optimal geometric parameters. A new series of submicromolar inhibitors was thus identified, which showed antiproliferative activity on HCT-116 colon carcinoma cells.
Rossi, Cristina,Porcelloni, Marina,D'Andrea, Piero,Fincham, Christopher I.,Ettorre, Alessandro,Mauro, Sandro,Squarcia, Antonella,Bigioni, Mario,Parlani, Massimo,Nardelli, Federica,Binaschi, Monica,Maggi, Carlo A.,Fattori, Daniela
supporting information; experimental part
p. 2305 - 2308
(2011/05/15)

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Chemical Properties

Melting Point: 157-159.5°
Boiling Point: 471.4°Cat760mmHg
Flash Point:238.9°C
Density: 1.366g/cm³
Vapor Pressure: 1.08E-09mmHg at 25°C
PSA: 83.06000
LogP: 2.19060

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