The first total synthesis of hirtellanines A is described. The key transformations include (i) base-mediated regioselective pyran ring formation, (ii) one-pot sequential boronation and Suzuki-Miyaura cross-coupling, and (iii) a tandem acid-induced deprotection and subsequent tautomerizations.
Studies on the total synthesis of Hirtellanine A: Regioselective synthesis of benzopyran
The total synthesis of Hirtellanine A was accomplished by two different synthetic approaches. Hirtellanine A was assembled using a one-pot, tandem acid-mediated deprotection and tautomerization cascade starting from quinone derivative 23. The key features