123293-72-1

Basic information

• Product Name: 2-Propenenitrile,3-(4-pyridinyl)-,(2E)-(9CI)
• Synonyms: 2-Propenenitrile,3-(4-pyridinyl)-,(2E)-(9CI);(E)-3-pyridin-4-ylprop-2-enenitrile
• CAS NO: 123293-72-1
• Molecular Formula: C₈H₆N₂
• Molecular Weight: 0
• Product Categories: PYRIDINE
• Mol File: 123293-72-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Propenenitrile,3-(4-pyridinyl)-,(2E)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenenitrile,3-(4-pyridinyl)-,(2E)-(9CI)(123293-72-1)
• EPA Substance Registry System: 2-Propenenitrile,3-(4-pyridinyl)-,(2E)-(9CI)(123293-72-1)

Safety Data

• Hazardous Substances Data: 123293-72-1(Hazardous Substances Data)

Upstream product

• 872-85-5 pyridine-4-carbaldehyde 
• 75-05-8 acetonitrile 
• 19524-06-2 4-bromopyridine hydrochloride 
• 107-13-1 acrylonitrile 
• 24166-09-4 (cyanomethyl)triphenylarsonium bromide 
• 2537-48-6 diethyl 1-cyanomethylphosphonate 

Relevant articles and documents

(E)-3-heteroaromatic propyl-2-enoic acid derivative as well as preparation and application thereof

The invention relates to a (E)-3-heteroaromatic propyl-2-enoic acid derivative, and also relates to a preparation method and pharmaceutical application thereof. The compound is a novel Nrf2 activatorand has the effects of resisting oxidative stress, resisting neuritis and enhancing mitochondrial functions and biogenesis by effectively activating an Nrf2 signal path, so that nerve cells are protected, and the compound can be used for treating neurodegenerative diseases and cerebral apoplexy. In addition, the novel Nrf2 activator can also be used to treat autoimmune diseases, diabetes and nephropathy, and other chronic diseases.

Synthesis of olefins via a Wittig reaction mediated by triphenylarsine

An arsine-mediated Wittig reaction for the synthesis of olefins is described. After heating triphenylarsine in the presence of an activated alkyl bromide for 30?min, the resulting arsonium salt condensed with aldehydes in as little as 5?min at room temperature, yielding the olefins in high yields. Aromatic, heteroaromatic, and alkyl aldehydes were all suitable substrates for this process.

Vinylpyridines as Building Blocks for the Photocatalyzed Synthesis of Alkylpyridines

The photocatalyzed addition of several hydrogen donors (ethers, aldehydes, alkanes, amides) onto vinylpyridines was achieved. This approach provided access to alkylpyridines, which are important building blocks for the preparation of compounds with biological activity. The strategy was very simple and straightforward because it required only a small amount of a cheap decatungstate salt as photocatalyst. As an added advantage, the reaction could be performed under sunlight irradiation as well as under flow conditions.

5, 7-SUBSTITUTED-IMIDAZO [1, 2-C] PYRIMIDINES AS INHIBITORS OF JAK KINASES

Compounds of Formula I: (Formula should be inserted here) and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3, R4, R5, R6, R7, X1 and X2 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.

Efficient synthesis of pyridylacrylonitriles via the Heck reaction

A new synthetic pathway to pyridylacrylonitriles has been developed based on a palladium-catalyzed Heck reaction. The optimized process and the preparation of related functionalized pyridylacrylonitriles are discussed. Copyright Taylor & Francis Group, LLC.

Horner-Emmons synthesis with minimal purification using ROMPGEL: A novel high-loading matrix for supported reagents

(Matrix presented) The synthesis and use of two novel high-loading Horner-Emmons ring-opening metathesis polymers are described. α,β-Unsaturated ethyl esters (E:Z> 99:1) and α,β-unsaturated nitriles (E:Z> 70:30) are obtained in excellent yields and purities from aldehydes with minimal purification.

Replacement Substituent Constants for Simple Heterocycles

13C nmr absorptions are reported for the β-vinylic carbon atoms in 15 series of ethylenes bearing heterocyclic substituents.The data are used to establish the best single-parameter substituent constants, ?13, for the various heterocycles as replacements for para-substituted benzenes.Also reported are replacement dual substituent constants, including ?I and the various ?R scales needed in the Taft DSP treatment and those for F and R used in the Swain-Lupton treatment.Values of ?13, F, R, ?I, and ?Ro, respectively, for the various heterocycles as replacements for para-substituted benzenes are as follows: 2-furyl, -1.01 , 0.99, -2.51, 0.65, -0.60; 2-pyrryl, -2.53, 0.52, -5.09, -0.16, -0.62; 2-thienyl, -0.79, 2.49, -3.60, 1.82, -1.08; 3-thienyl, -0.40, 1.04, -1.57, 0.59, -0.39; 2-pyridyl, 0.88, 2.09, -0.24, 1.65, -0.45; 3-pyridyl, 0.60, 0.57, 0.63, 0.35, 0.04; and 4-pyridyl, 1.18, 1.22, 1.09, 0.92, -0.01.The DSP-NLR method of analysis is explored using electron demand parameters, ε, as determined for the vinylic side chains in para-substituted styrenes.