- The ready conversion of anguidine into verrucarol and trichodermol
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Anguidine, 1, is readily converted into verrucarol diacetate, 2d, in 85 percent yield by application of the Barton-McCombie deoxygenation procedure. To enable conversion into trichodermol, 3a, the primary hydroxyl group of verrucarol, 2a, is selectively acetylated or is selectively acetylated or preferably silylated, thereby paving the way for its deoxygenation in three simple, high-yield reactions.
- Tulshian, Deen Bandhu,Fraser-Reid, Bert
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- RORIDIN L-2, A NEW TRICHOTHECENE
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The structure (2) of roridin L-2 is shown to be a C29-trichothecene that lacks the macrocyclic lactone system usually present in the roridins.
- Bloem, Russell J.,Smitka, Tim A.,Bunge, Richard H.,French, James C.,Mazzola, Eugene P.
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