
Tetrahedron Letters p. 4549 - 4552 (1980)
Update date:2022-07-31
Topics:
Tulshian, Deen Bandhu
Fraser-Reid, Bert
Anguidine, 1, is readily converted into verrucarol diacetate, 2d, in 85 percent yield by application of the Barton-McCombie deoxygenation procedure. To enable conversion into trichodermol, 3a, the primary hydroxyl group of verrucarol, 2a, is selectively acetylated or is selectively acetylated or preferably silylated, thereby paving the way for its deoxygenation in three simple, high-yield reactions.
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