- Preparation method of benzphetamine hydrochloride
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The invention relates to the field of chemical pharmacy, and in particular relates to a preparation method of benzphetamine hydrochloride. According to the method, the use of controlled products suchas ephedrine, pseudoephedrine, deoxyephedrine and the like is avoided; the raw materials are cheap and easy to obtain, so that the synthesis cost is reduced; by using the preparation method disclosedby the invention, the high-purity target compound can be obtained at high yield, and industrial large-scale production is easy.
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- General access to chiral n -alkyl terminal aziridines via organocatalysis
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(Figure Presented) A three step, one-pot protocol involving enantioselective α-chlorination of aldehydes, subsequent reductive amination with a primary amine, and SN2 displacement to afford chiral N-alkyl terminal aziridines in 40-65% yield (74-87%/step) and, in most cases, >90% ee is reported.
- Fadeyi, Olugbeminiyi O.,Schulte, Michael L.,Lindsley, Craig W.
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supporting information; experimental part
p. 3276 - 3278
(2010/10/21)
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