1234572-14-5

Basic information

• Product Name: (R)-1,2-dibenzylaziridine
• Synonyms: (R)-1,2-dibenzylaziridine
• CAS NO: 1234572-14-5
• Molecular Weight: 223.318
• Mol File: 1234572-14-5.mol

Chemical Properties

• CAS DataBase Reference: (R)-1,2-dibenzylaziridine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1,2-dibenzylaziridine(1234572-14-5)
• EPA Substance Registry System: (R)-1,2-dibenzylaziridine(1234572-14-5)

Safety Data

• Hazardous Substances Data: 1234572-14-5(Hazardous Substances Data)

Upstream product

• 673-06-3 D-(R)-phenylalanine 
• 5267-64-1 (R)-2-amino-3-phenylpropanol 
• 100-44-7 benzyl chloride 
• 77184-95-3 (R)-2-benzylaziridine 

Downstream Products

• 15062-72-3 N-Demethylbenzphetamine 

Relevant articles and documents

Preparation method of benzphetamine hydrochloride

The invention relates to the field of chemical pharmacy, and in particular relates to a preparation method of benzphetamine hydrochloride. According to the method, the use of controlled products suchas ephedrine, pseudoephedrine, deoxyephedrine and the like is avoided; the raw materials are cheap and easy to obtain, so that the synthesis cost is reduced; by using the preparation method disclosedby the invention, the high-purity target compound can be obtained at high yield, and industrial large-scale production is easy.

General access to chiral n -alkyl terminal aziridines via organocatalysis

(Figure Presented) A three step, one-pot protocol involving enantioselective α-chlorination of aldehydes, subsequent reductive amination with a primary amine, and SN2 displacement to afford chiral N-alkyl terminal aziridines in 40-65% yield (74-87%/step) and, in most cases, >90% ee is reported.