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1235005-44-3

N-Fmoc-2,6-difluoro-L-phenylalanine is a chemical compound utilized in organic chemistry and peptide synthesis. It is a derivative of the amino acid phenylalanine, featuring two fluorine atoms at the 2 and 6 positions on the phenyl ring. The "N-Fmoc" prefix signifies that the N-terminus of the amino acid is shielded by the Fmoc (9-fluorenylmethoxycarbonyl) group, allowing for mild condition removal to expose the free amine group for subsequent chemical reactions. This molecule serves as a building block in the synthesis of fluorinated peptides and peptidomimetics, which may have applications in drug discovery and development due to their distinct chemical and pharmacological properties. N-Fmoc-2,6-difluoro-L-phenylalanine is a significant chemical tool for creating novel bioactive compounds and molecular probes in medicinal chemistry and chemical biology.

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  • 1235005-44-3 Structure

  • Basic information

    1. Product Name: N-Fmoc-2,6-difluoro-L-phenylalanine
    2. Synonyms: N-Fmoc-2,6-difluoro-L-phenylalanine;(9H-Fluoren-9-yl)MethOxy]Carbonyl Phe(2,6-DiF)-OH;Fmoc-L-2,6-Difluorophenylalanine
    3. CAS NO:1235005-44-3
    4. Molecular Formula: C24H19F2NO4
    5. Molecular Weight: 423.4087664
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1235005-44-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 614.9±55.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.357±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. PKA: 3.76±0.15(Predicted)
    10. CAS DataBase Reference: N-Fmoc-2,6-difluoro-L-phenylalanine(CAS DataBase Reference)
    11. NIST Chemistry Reference: N-Fmoc-2,6-difluoro-L-phenylalanine(1235005-44-3)
    12. EPA Substance Registry System: N-Fmoc-2,6-difluoro-L-phenylalanine(1235005-44-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1235005-44-3(Hazardous Substances Data)

1235005-44-3 Usage

Uses

Used in Pharmaceutical Industry:
N-Fmoc-2,6-difluoro-L-phenylalanine is used as a building block for the synthesis of fluorinated peptides and peptidomimetics for their potential applications in drug discovery and development. The unique chemical and pharmacological properties of these compounds make them valuable in creating new therapeutic agents.
Used in Medicinal Chemistry:
N-Fmoc-2,6-difluoro-L-phenylalanine is used as a key component in the synthesis of novel bioactive compounds, contributing to the advancement of medicinal chemistry by enabling the creation of molecules with specific biological activities.
Used in Chemical Biology:
N-Fmoc-2,6-difluoro-L-phenylalanine is utilized as a molecular probe in chemical biology, aiding researchers in understanding complex biological processes and interactions through the synthesis of tailored fluorinated peptides and peptidomimetics.

Check Digit Verification of cas no

The CAS Registry Mumber 1235005-44-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,3,5,0,0 and 5 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1235005-44:
(9*1)+(8*2)+(7*3)+(6*5)+(5*0)+(4*0)+(3*5)+(2*4)+(1*4)=103
103 % 10 = 3
So 1235005-44-3 is a valid CAS Registry Number.

1235005-44-3Downstream Products

1235005-44-3Relevant articles and documents

Kras inhibitory cyclic peptide compound

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Paragraph 0362; 0617-0618, (2021/06/03)

The following were discovered: a cyclic peptide compound that interacts with Ras; and an unnatural amino acid that is useful in the production of said cyclic peptide compound. The cyclic peptide compound was also discovered to inhibit bonding between Ras and SOS. The following were additionally discovered: a specific unnatural amino acid included in said cyclic peptide compound; and a manufacturing method therefor.

MASP INHIBITORY COMPOUNDS AND USES THEREOF

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Page/Page column 207, (2020/11/23)

The present invention relates to novel Mannose-binding lectin (MBL)-associated serine protease (MASP) inhibitory compounds, as well as analogues and derivatives thereof, to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of renal and cardiovascular disorders and of ischemia reperfusion injuries.

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