1235469-00-7

Basic information

• Product Name: 1-Methylindazole-5-boroni...
• Synonyms: 1-Methylindazole-5-boroni...;1-Methyl-1H-indazol-5-ylboronic acid pinacol ester;1H-Indazole, 1-Methyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-;1-methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole;1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)
• CAS NO: 1235469-00-7
• Molecular Formula: C₁₄H₁₉BN₂O₂
• Molecular Weight: 258.12386
• Product Categories: 6
• Mol File: 1235469-00-7.mol

Chemical Properties

• Boiling Point: 385.0±15.0 °C(Predicted)
• Appearance: /
• Density: 1.11±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 1.51±0.30(Predicted)
• CAS DataBase Reference: 1-Methylindazole-5-boroni...(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methylindazole-5-boroni...(1235469-00-7)
• EPA Substance Registry System: 1-Methylindazole-5-boroni...(1235469-00-7)

Safety Data

• Hazardous Substances Data: 1235469-00-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
1-Methylindazole-5-boronic acid is used as a key intermediate in the synthesis of pharmaceutical drugs for various therapeutic applications. Its ability to form stable covalent bonds makes it a valuable component in the creation of new drug candidates with improved efficacy and selectivity.
Used in Organic Synthesis:
In the field of organic synthesis, 1-Methylindazole-5-boronic acid is employed as a versatile building block for the construction of complex organic molecules. Its reactivity with nucleophiles allows for the formation of new chemical entities with potential applications in various industries.
Used in Agrochemical Development:
1-Methylindazole-5-boronic acid is also utilized in the development of agrochemicals, contributing to the synthesis of compounds with pesticidal or herbicidal properties. Its incorporation into these products can lead to more effective and targeted agricultural solutions.

Upstream product

• 53857-57-1 5-bromo-1H-indazole 
• 465529-57-1 5-bromo-1-methyl-1H-indazole 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 1607837-31-9 8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one 
• 1229207-08-2 N-(3,4-dimethoxyphenyl)-6-(1-methyl-1H-indazol-5-yl)imidazo[1,2-a]pyrazin-8-amine 

Relevant articles and documents

Discovery of a potent, highly selective, and orally bioavailable inhibitor of CDK8 through a structure-based optimisation

CDK8 is deregulated in multiple types of human cancer and is viewed as a therapeutic target for the treatment of the disease. Accordingly, the search for small-molecule inhibitors of CDK8 is being intensified. Capitalising on our initial discovery of AU1-100, a potent CDK8 inhibitor yet with a limited degree of kinase selectivity, a structure-based optimisation was carried out, with a series of new multi-substituted pyridines rationally designed, chemically prepared and biologically evaluated. Such endeavour has culminated in the identification of 42, a more potent CDK8 inhibitor with superior kinomic selectivity and oral bioavailability. The mechanism underlying the anti-proliferative effect of 42 on MV4-11 cells was studied, revealing that the compound arrested the G1 cell cycle and triggered apoptosis. The low risk of hepato- and cardio-toxicity of 42 was estimated. These findings merit further investigation of 42 as a targeted cancer therapeutic.

Heterocyclic compound with Wnt signal path inhibitory activity and application thereof

The invention provides a heterocyclic compound with Wnt signal path inhibitory activity. The heterocyclic compound and chemically acceptable salt, isotope, isomer and a crystal structure thereof are provided with a structure shown as the general formula I (see the formula in the description). The invention further provides application of the heterocyclic compound with the Wnt signal path inhibitory activity. The heterocyclic compound with the Wnt signal path inhibitory activity serves as effective antagonist of a Wnt signal path, and can be used for treating or preventing diseases caused by abnormity of the Wnt signal path.

SUBSTITUTED PYRIDOPYRAZINES AS SYK INHIBITORS

The present invention relates to pyridopyrazine compounds of formula (I), pharmaceutical compositions thereof and methods of use therefore, wherein R1, R2, R3, L, m, p and W are as defined in the specification.