1607837-31-9 Usage
Description
8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one is a complex chemical compound characterized by a unique spiro ring system and a variety of functional groups. It features an amino group, a chloro group, a pyridine ring, and a methyl-indazole moiety. This distinctive molecular structure may offer potential applications in medicinal chemistry, particularly in the fields of drug discovery and development. Further research is required to explore the compound's properties and its full potential for use.
Uses
Used in Pharmaceutical Industry:
8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one is used as a potential candidate in drug discovery for its unique molecular structure and functional groups. Its potential applications may include the development of new therapeutic agents targeting various diseases and conditions.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one serves as a subject of study to understand its properties, interactions with biological targets, and possible mechanisms of action. This research can contribute to the advancement of drug design and the discovery of novel therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 1607837-31-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,0,7,8,3 and 7 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1607837-31:
(9*1)+(8*6)+(7*0)+(6*7)+(5*8)+(4*3)+(3*7)+(2*3)+(1*1)=179
179 % 10 = 9
So 1607837-31-9 is a valid CAS Registry Number.
1607837-31-9Relevant articles and documents
Discovery of a potent, highly selective, and orally bioavailable inhibitor of CDK8 through a structure-based optimisation
Yu, Mingfeng,Long, Yi,Yang, Yuchao,Li, Manjun,Teo, Theodosia,Noll, Benjamin,Philip, Stephen,Wang, Shudong
, (2021/04/09)
CDK8 is deregulated in multiple types of human cancer and is viewed as a therapeutic target for the treatment of the disease. Accordingly, the search for small-molecule inhibitors of CDK8 is being intensified. Capitalising on our initial discovery of AU1-100, a potent CDK8 inhibitor yet with a limited degree of kinase selectivity, a structure-based optimisation was carried out, with a series of new multi-substituted pyridines rationally designed, chemically prepared and biologically evaluated. Such endeavour has culminated in the identification of 42, a more potent CDK8 inhibitor with superior kinomic selectivity and oral bioavailability. The mechanism underlying the anti-proliferative effect of 42 on MV4-11 cells was studied, revealing that the compound arrested the G1 cell cycle and triggered apoptosis. The low risk of hepato- and cardio-toxicity of 42 was estimated. These findings merit further investigation of 42 as a targeted cancer therapeutic.
2-AMINOPYRIDINE COMPOUNDS
-
, (2014/05/24)
The invention provides novel substituted 2-aminopyridine compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases such as cancer, inflammatory or degenerative diseases.
