- Synthesis method of novel complex for drug testing
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The invention relates to a synthesis method of a novel complex for drug testing, in particular to a Pb-containing complex Pb(bpbp)3(NO3)2, wherein bpbp represents 2,6-bis(2-(1-phenyl)benzimidazole)pyridine. The invention further relates to a crystal structure of the complex. The preparation method is simple and fast, and the complex is low in toxicity and high in yield. Compared with a conventional crystal culture method of the ligand complexes, the method has the advantages that solvents for synthesis are water and methanol, and a large quantity of crystals can be obtained in three days. Withadoption of a fluorescence analysis method, a fluorescence spectrum of interaction of a target product and BSA (bovine serum albumin) is tested; the fluorescence quenching phenomenon of BSA indicatesthat the complex has stronger interaction with BSA, so that the complex can be applied to biological drug detection.
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Paragraph 0028; 0040; 0044
(2018/05/16)
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- A 2, 6 - di (2 - (1 - phenyl) benzimidazole) pyridine preparation method (by machine translation)
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The invention relates to a 2, 6 - di (2 - (1 - phenyl) benzimidazole) pyridine of the preparation method, adopt the one-step reduction guan Huanfa synthesis: the 2 - nitro diphenylamine, 2, 6 - pyridine-phthalaldehyde, reducing agent, solvent and the like according to appropriate ratio after being mixed 100 °C reflow conditions 24h can be, to overcome the traditional benzimidazole compound of preparation requires high temperature or microwave condition and the protection of inert gas atmosphere for a long time under the defect of the reaction. In addition, the invention adopts the preparation method does not need to carry out the drying treatment of the solvent, also does not need to nitrogen or argon and other inert gas protection, reduces energy consumption; and the product after treatment is simple, conversion is relatively high, the resulting yield of a target product can be up to 47%, and the invention uses the apparatus is relatively simple, wide sources of raw materials, the cost is low, the invention has obvious economic and environmental benefit. (by machine translation)
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Paragraph 0047; 0048
(2017/08/25)
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- Synthesis of Ruthenium Complex Based on 2,6-Bis(1-(phenyl)-1H-benzo[d]imidazol-2-yl)pyridine and 2-(1-Phenyl-1H-benzo[d]imidazol-2-yl)benzoate and Catalytical Oxidation Property of 1-(1H-Benzo[d]imidazol-2-yl)ethanol to 1-(1H-Benzo[d]imidazol-2-yl)ethanone with H2O2
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A new ruthenium complex, Ru(bpbp)(pbb)Cl, based on 2,6-bis(1-(phenyl)-1H-benzo[d]imidazol-2-yl)pyridine (bpbp) and 2-(1-phenyl-1H-benzo[d]imidazol-2-yl)benzoate (pbb) was synthesized. The complex Ru(bpbp)(pbb)Cl could catalytically oxidize 1-(1H-benzo[d]imidazol-2-yl)ethanol to 1-(1H-benzo[d]imidazol-2-yl)ethanone with H2O2 as oxidant. Influence of temperature and catalyst amount on the oxidation reaction was evaluated. The reaction optimal conditions are as follows: molar ratio of catalyst to substrate to H2O2 is 1: 1000: 3000, the proper reaction temperature is 50°C and reaction time lasts 5 h, and the isolated yield of 1-(1H-benzo[d]imidazol-2-yl)ethanol to 1-(1H-benzo[d]imidazol-2-yl)ethanone under the optimal reaction conditions is 57%.
- Liu, Shenggui,Pan, Rongkai,Li, Guobi,Su, Wenyi,Ni, Chunlin
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- Zinc(ii) complexes containing bis-benzimidazole derivatives as a new class of apoptosis inducers that trigger DNA damage-mediated p53 phosphorylation in cancer cells
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In the present study, two zinc(ii) complexes containing bis-benzimidazole derivatives, Zn(bpbp)Cl2 (1) and [Zn(bpbp)2](ClO 4)2·CH3CH2OH·H 2O (2) (bpbp = 2,6-bis(1-phenyl-1H-benzo[d]imidazol-2-yl)pyridine), have been designed, synthesized and evaluated for their in vitro anticancer activities. The underlying molecular mechanisms through which they caused the cancer cell death were also elucidated. The complexes were identified as potent antiproliferative agents against a panel of five human cancer cell lines by comparing with cisplatin. Complex 2 demonstrated dose-dependent growth inhibition on MCF-7 human breast carcinoma cells with IC50 at 2.9 μM. Despite this potency, the complexes possessed great selectivity between human cancer cells and normal cells. Induction of apoptosis in MCF-7 cells by complex 2 was evidenced by accumulation of sub-G1 cell population, DNA fragmentation and nuclear condensation. Further investigation on intracellular mechanisms revealed that complex 2 was able to induce p53-dependent apoptosis in cancer cells by triggering DNA damage. On the basis of this evidence, we suggest that Zn(ii) complexes containing bis-benzimidazole derivatives may be candidates for further evaluation as chemotherapeutic agents for human cancers.
- Liu, Shenggui,Cao, Wenqiang,Yu, Lianling,Zheng, Wenjie,Li, Linlin,Fan, Cundong,Chen, Tianfeng
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p. 5932 - 5940
(2013/07/25)
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- Selective iron-catalyzed oxidation of benzylic and allylic alcohols
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A convenient and selective oxidation of alcohols with hydrogen peroxide to give aldehydes and ketones has been developed. Using in situ generated iron chloride complexes [Fe(L3)2Cln] [n=0-1, L3 =6-(N-phenylbenzimidazoyl)-2-pyridinecarboxylic acid], aldehydes and ketones were obtained in good yield and excellent selectivity after a short reaction time at room temperature. Copyright
- Join, Benoit,Moeller, Konstanze,Ziebart, Carolin,Schroeder, Kristin,Goerdes, Dirk,Thurow, Kerstin,Spannenberg, Anke,Junge, Kathrin,Beller, Matthias
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p. 3023 - 3030
(2011/12/21)
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