- BRIDGED TETRAHYDRONAPHTHALENE DERIVATIVES
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The invention relates to compounds of formula (I) wherein R1, R2, R3, R4, A, B, W and n are as defined in the description, and to pharmaceutically acceptable salts of such compounds. These compounds are useful as calcium channel blockers.
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Page/Page column 31
(2010/05/13)
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- Synthesis of Some Benzimidazole-, Pyridine- and Imidazole-Derived Chelating Agents
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Procedures are described for the preparation of various bidentate and potentially tridentate chelating agents.These incorporate pyridyl, benzimidazole, imidazole or phenolic moieties.Phillips condensations of carboxylic acids with o-phenylenediamines were carried out in 4 M hydrochloric acid.Syntheses are reported for 2,6-bis(N'-methylimidazol-2'-ylthiomethyl)pyridine, 2,6-bis(benzimidazol-2'-ylthiomethyl)pyridine, 2-(4'-piperidyl)benzimidazole, 2-(3'-piperidyl)benzimidazole, 2-(3-N'-methylpiperidyl)benzimidazole, 2-(3-N'-methylpiperidyl)-N-methylbenzimidazole, 2-(2'-hydroxybenzyl)benzimidazole and 2-(2'-hydroxybenzyl)-N-methylbenzimidazole.The compounds were characterized where appropriate by their mass, uv, and 1H-nmr spectra. 2-(2'-Hydroxybenzyl)benzimidazole hydrochloride acts as a gelling agent in aqueous solution.
- Wahlgren, Curtis G.,Addison, Anthony W.
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p. 541 - 543
(2007/10/02)
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