- Synthesis of branched monodisperse oligoethylene glycols and 19f mri-traceable biomaterials through reductive dimerization of azides
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Multifunctionalized and branched M-OEGs represent valuable PEGylation agents, linkers, and scaffolds in biomedicine. However, the tedious synthesis limited their availability and application. We herein present an azide reductive dimerization method for the convenient synthesis of aza-M-OEGs and derivatives, which provides easy access to a variety of multifunctionalized and branched M-OEGs in one step. With this method, hexa-arm M-OEGs with 54 symmetrical fluorines were synthesized in two steps as a water-soluble, self-assemble, 19F MRI sensitive, and biocompatible dendritic biomaterial.
- Chen, Shizhen,Jiang, Zhong-Xing,Li, Yu,Yang, Hao,Yang, Zhigang,Yuan, Yuan,Zhang, Huaibin,Zhang, Jing,Zhou, Xin
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p. 6778 - 6787
(2020/06/08)
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- SHORT CHAIN PEGYLATION OF AMINO ACID MONOMERS GLUTAMINE AND LYSINE AND PEPTIDES FORMED THEREBY
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Novel synthesized amino acids of glutamine and lysine that are directly PEGylated with small, monodisperse PEGs, and a novel process for creating novel amino acid monomers using PEGylation. These amino acids are readily incorporated into peptides for a range of different applications.
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- Monodisperse perfluoro-polyethoxylated amphiphilic compounds with two-chain polar head - Preparation and properties
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Monodisperse new surfactant molecules with a two-chain polyoxyethylene (EO) hydrophilic head and a perfluoroalkyl hydrophobic moiety linked together through an amide bond are synthesized by methods allowing large-scale production. Surface tension measurements (γ ~ 20 mN·m-1) show slow organization of the surfactant film at the water/air interface for longer fluorocarbon tail. Values of critical micellar concentrations and comparisons with monosubstituted amide surfactants are consistent with a high hydrophilicity of the amide function, a small influence of branching over hydrophilicity, and a hydrophobicity of each CF2 unit equivalent to 1.7 methylenes (in the analogous hydrogenated surfactants).
- Selve,Ravey,Stebe,El Moudjahid,Moumni,Delpuech
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p. 411 - 428
(2007/10/02)
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- Synthesis of Novel Perfluoroalkyl Nonionic Surfactants with a Bipodal Hydrophilic Moiety
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Monodisperse perfluoroalkyl N,N'-polyethoxylated amides, synthesized as dimethyl ether derivatives, CnF(2n+1)CH2C(O)N(mMe)2 are efficient bipodal nonionic fluorinated surfactants.
- Selve, Claude,Moumni, El Mostafa,Delpuech, Jean-Jacques
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p. 1437 - 1438
(2007/10/02)
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