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CAS

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123955-10-2

Almokalant is a class III anti-arrhythmic agent that selectively blocks the delayed rectifier potassium current in cardiac myocytes. It is characterized by its ability to prolong the action potential duration and refractory period of the heart, playing a crucial role in the management of atrial fibrillation/flutter and other cardiac arrhythmias. Almokalant functions by binding to and blocking potassium channels in heart muscle cells, thus preventing rapid repolarization that can trigger abnormal heart rhythms. Despite its therapeutic potential, its clinical use is restricted due to the risk of life-threatening ventricular arrhythmias, and it is predominantly utilized for research in the field of cardiac electrophysiology and arrhythmias.

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  • 123955-10-2 Structure

  • Basic information

    1. Product Name: Almokalant
    2. Synonyms: Almokalant
    3. CAS NO:123955-10-2
    4. Molecular Formula: C18H28N2O3S
    5. Molecular Weight: 352.496
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 123955-10-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 574.8°Cat760mmHg
    3. Flash Point: 301.4°C
    4. Appearance: /
    5. Density: 1.17g/cm3
    6. Vapor Pressure: 4.73E-14mmHg at 25°C
    7. Refractive Index: 1.567
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: Almokalant(CAS DataBase Reference)
    11. NIST Chemistry Reference: Almokalant(123955-10-2)
    12. EPA Substance Registry System: Almokalant(123955-10-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 123955-10-2(Hazardous Substances Data)

123955-10-2 Usage

Uses

Used in Cardiology:
Almokalant is used as an anti-arrhythmic agent for the treatment of atrial fibrillation/flutter and other cardiac arrhythmias. It serves to prolong the action potential duration and refractory period of the heart, which helps in stabilizing abnormal heart rhythms.
Used in Research:
Almokalant is used as a research tool in the study of cardiac electrophysiology and arrhythmias. Its selective blocking action on the delayed rectifier potassium current in cardiac myocytes provides valuable insights into the mechanisms of cardiac rhythm regulation and the development of novel therapeutic strategies for arrhythmia management.
However, it is important to note that the use of Almokalant in clinical settings is limited due to its potential for causing life-threatening ventricular arrhythmias. As a result, its primary application remains in the realm of research, where it contributes to a deeper understanding of cardiac function and the pathophysiology of arrhythmias.

Check Digit Verification of cas no

The CAS Registry Mumber 123955-10-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,9,5 and 5 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 123955-10:
(8*1)+(7*2)+(6*3)+(5*9)+(4*5)+(3*5)+(2*1)+(1*0)=122
122 % 10 = 2
So 123955-10-2 is a valid CAS Registry Number.
InChI:InChI=1/C18H28N2O3S/c1-3-11-24(22)12-5-10-20(4-2)14-17(21)15-23-18-8-6-16(13-19)7-9-18/h6-9,17,21H,3-5,10-12,14-15H2,1-2H3

123955-10-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-[3-[ethyl(3-propylsulfinylpropyl)amino]-2-hydroxypropoxy]benzonitrile

1.2 Other means of identification

Product number -
Other names 4-(3-(Ethyl(3-(propylsulfinyl)propyl)amino)-2-hydroxypropoxy)benzonitrile

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:123955-10-2 SDS

123955-10-2Downstream Products

123955-10-2Relevant articles and documents

Polystyrenesulfonate-drug complex and solid dosage forms thereof

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, (2008/06/13)

Almokalant (p-INN), 4-[3-]ethyl[3-(propylsulfinyl)propyl]amino[-2-hydroxypropoxy]-benzonitrile, having the formula STR1 is a member of a group of compounds useful in the treatment of cardiac arrhythmias. Enhanced stability, palatability, and technical pro

Novel polystyrenesulfonate, useful against cardiac arrhythmias

-

, (2008/06/13)

A salt of 4-[3-[3-[ethyl-[3-(propylsulfinyl)propyl]amino]-2-hydroxyproproxy]-benzonitrile having the formula I STR1 with polystyrenesulponic acid, which is useful for the treatment of cardiac arrhythmia, process for the preparation of said salt as well as the use of said salt for the preparation of medicaments with action against cardiac arrhythmias.

Stereoisomers of benzonitrile derivatives, useful as cardiac arrhythmiac agents

-

, (2008/06/13)

4-[3-[ethyl[3-((R*)-propylsulfinyl)propyl]amino]-2(R)-hydroxypropoxy]-benzonitrile, 4-[3-[ethyl[3-((S*)-propylsulfinyl)propyl]amino]-2(R)-hydroxypropoxy]-benzonitrile, 4-[3-[ethyl[3-((R*)-propylsulfinyl)propyl]amino]-2(S)-hydroxypropoxy]-benzonitrile, 4-[3-[ethyl[3-[((S*)-propylsulfinyl)propyl]amino]-2(S)-hydroxypropoxy]-benzonitrile and pharmaceutically acceptable salt thereof, processes for their preparation, as well as the use of said compounds for the preparation of medicaments with action against cardiac arrhythmias.

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