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Usage

Uses

Used in Pharmaceutical Industry:
(R)-4-(OXIRAN-2-YLMETHOXY)BENZONITRILE is used as an intermediate for the synthesis of various pharmaceutical ingredients. Its application is due to its ability to act as a versatile building block, contributing to the development of new drug candidates.
Used in Agrochemical Industry:
In the field of agrochemicals, (R)-4-(OXIRAN-2-YLMETHOXY)BENZONITRILE is used as a precursor for the development of new agricultural products. Its potential applications in this industry are attributed to its role in creating innovative products that can enhance agricultural practices and outcomes.

Upstream product

• 51594-55-9 (R)-(-)-epichlorohydrin 
• 767-00-0 4-cyanophenol 
• 134645-02-6 (2R)-1-(4-cyanophenoxy)-3-methanesulfonyloxypropan-2-ol 

Downstream Products

• 123955-10-2 almokalant 
• 133521-52-5 4-[3-[ethyl[3-((S*)-propylsulfinyl)propyl]amino]-2(R)-hydroxypropoxy]benzonitrile 
• 349447-28-5 4-{[(2R)-3-amino-2-hydroxypropyl]oxy}benzonitrile 

Relevant academic research and scientific papers

PROCESS FOR THE ISOLATION OF 4-(OXIRANYLMETHOXY)-BENZONITRILES

There is provided a process for the isolation of a compound of formula I, or a solvate thereof, from a mixture comprising a compound of formula I and a compound of formula II, wherein the mixture of compounds of formulae I and II may be prepared by reacti

Bispidine compounds useful in the treatment of cardiac arrythmias

There is provided compounds of formula I, 1 wherein R1, R2, R3, R4, R5, R6, R7, R41, R42, R43 R44, R45, R46, A and B have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.

Bispidine antiarrhythmic compounds

There is provided a compound of formula I, wherein R1, R2, R9, R10, R11, R12, X, A and B have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.

Polystyrenesulfonate-drug complex and solid dosage forms thereof

Almokalant (p-INN), 4-[3-]ethyl[3-(propylsulfinyl)propyl]amino[-2-hydroxypropoxy]-benzonitrile, having the formula STR1 is a member of a group of compounds useful in the treatment of cardiac arrhythmias. Enhanced stability, palatability, and technical pro

Stereoisomers of benzonitrile derivatives, useful as cardiac arrhythmiac agents

4-[3-[ethyl[3-((R*)-propylsulfinyl)propyl]amino]-2(R)-hydroxypropoxy]-benzonitrile, 4-[3-[ethyl[3-((S*)-propylsulfinyl)propyl]amino]-2(R)-hydroxypropoxy]-benzonitrile, 4-[3-[ethyl[3-((R*)-propylsulfinyl)propyl]amino]-2(S)-hydroxypropoxy]-benzonitrile, 4-[3-[ethyl[3-[((S*)-propylsulfinyl)propyl]amino]-2(S)-hydroxypropoxy]-benzonitrile and pharmaceutically acceptable salt thereof, processes for their preparation, as well as the use of said compounds for the preparation of medicaments with action against cardiac arrhythmias.

Novel polystyrenesulfonate, useful against cardiac arrhythmias

A salt of 4-[3-[3-[ethyl-[3-(propylsulfinyl)propyl]amino]-2-hydroxyproproxy]-benzonitrile having the formula I STR1 with polystyrenesulponic acid, which is useful for the treatment of cardiac arrhythmia, process for the preparation of said salt as well as the use of said salt for the preparation of medicaments with action against cardiac arrhythmias.