123984-00-9

Basic information

• Product Name: Z-PRO-LEU-ALA-NHOH
• Synonyms: Z-PRO-LEU-ALA-NHOH;Collagenase Inhibitor (MMP1)
• CAS NO: 123984-00-9
• Molecular Formula: C₂₂H₃₂N₄O₆
• Molecular Weight: 448.51
• Mol File: 123984-00-9.mol

Chemical Properties

• Appearance: /
• Storage Temp.: -15°C
• CAS DataBase Reference: Z-PRO-LEU-ALA-NHOH(CAS DataBase Reference)
• NIST Chemistry Reference: Z-PRO-LEU-ALA-NHOH(123984-00-9)
• EPA Substance Registry System: Z-PRO-LEU-ALA-NHOH(123984-00-9)

Safety Data

• Hazardous Substances Data: 123984-00-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Z-PRO-LEU-ALA-NHOH is used as an inhibitor for interstitial collagenase and human matrix metalloproteinases (MMPs) for their role in regulating the breakdown of extracellular matrix components. This makes it a potential therapeutic agent for conditions where MMPs are overexpressed or dysregulated, such as various types of cancer and inflammatory diseases.
Used in Research Applications:
In the field of research, Z-PRO-LEU-ALA-NHOH serves as a valuable tool for studying the function and regulation of MMPs. By inhibiting these enzymes, researchers can gain insights into their role in various biological processes and develop a better understanding of the underlying mechanisms involved in disease progression.
Used in Drug Development:
Z-PRO-LEU-ALA-NHOH can be utilized in the development of new drugs targeting MMPs, which are known to be involved in the pathogenesis of numerous diseases. By incorporating this peptide into drug design, researchers can potentially create more effective and targeted therapies for conditions where MMP inhibition is beneficial.
Used in Cosmetic Industry:
In the cosmetic industry, Z-PRO-LEU-ALA-NHOH may be used as an ingredient in anti-aging products due to its potential to modulate MMP activity. By inhibiting these enzymes, the peptide could help reduce the breakdown of collagen and other structural proteins in the skin, thereby promoting skin health and reducing the appearance of wrinkles and other signs of aging.

Upstream product

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• 123983-98-2 (S)-2-[1-((S)-1-Hydroxycarbamoyl-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 123984-16-7 [1-((S)-1-Benzyloxycarbamoyl-ethylcarbamoyl)-3-methyl-butyl]-carbamic acid tert-butyl ester 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 3422-03-5 benzyloxycarbonyl azide 
• 123984-21-4 (S)-Pyrrolidine-2-carboxylic acid [1-((S)-1-hydroxycarbamoyl-ethylcarbamoyl)-3-methyl-butyl]-amide; hydrochloride 
• 123984-18-9 (S)-2-[(S)-1-((S)-1-Benzyloxycarbamoyl-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 123983-98-2 (S)-2-[(S)-1-((S)-1-Hydroxycarbamoyl-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 123984-16-7 Boc-Leu-Ala-NHOBzl 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 123984-21-4 HCl*Pro-Leu-Ala-NHOH 

Relevant articles and documents

Synthesis of hydroxamic acid derivatives

This invention is direct to a solid phase reaction product of a solid substrate carrying a plurality of covalently bound hydroxylamine or protected hydroxylamine groups. The solid solid phase reaction product may be used for the synthesis of hydroxamic ac