Structure-Activity Relationships of N2-Substituted Guanines as Inhibitors of HSV1 and HSV2 Thymidine Kinases
A series of N2-phenylguanines was synthesized and tested for inhibition of the thymidine kinases encoded by Herpes simplex viruses type 1 and type 2.Compounds with hydrophobic, electron-attracting groups in the meta position of the phenyl ring