124052-92-2

The invention relates to a new process for the preparation of 5-hydroxy-3,4,5,6-tetrahydro-pyrimidine derivatives of the general formula (I) STR1 in which R represents optionally substituted alkyl, which is characterized in that amidines of the general formula (II), STR2 in which R has the abovementioned meaning, are reacted with epichlorohydrin of the formula (III) STR3 if appropriate in the presence of a diluent at temperatures between 0° C. and 150° C.

A process for the preparation of a compound of the formula STR1 in which R is hydrogen, alkoxy, alkylamino, dialkylamino or an optionally substituted radical from the group consisting of alkyl, cycloalkyl, aralkyl and aryl, R1 is an optionally substituted radical from the group consisting of alkyl, alkoxy, alkylthio, mono- or dialkylamino and phenyl, R2 is optionally substituted alkyl, and Y is oxygen or sulphur, comprising (a1) reacting a compound of the formula STR2 with STR3 or with in which R5 is R except for hydrogen, or equivalent, to produce STR4 oxidizing that compound or its salt to STR5 and phosphorylating. Several of the intermediates are new.