- Novel Axially Chiral Ligand-Enabled Copper-Catalyzed Asymmetric Oxidative Coupling of 2-Naphthols for the Synthesis of 6,6′-Disubstituted BINOLs
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Novel axially chiral ligands have been designed and synthesized by merging the chelating picolinic acid with substituted BINOLs. The in-situ-prepared copper catalysts from the ligands and CuI enable the asymmetric oxidative coupling of 2-naphthols, afford
- Wang, Pengyang,Cen, Shouyi,Gao, Jun,Shen, Ahui,Zhang, Zhipeng
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p. 2321 - 2326
(2022/04/07)
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- Double-Fold Ortho and Remote C-H Bond Activation/Borylation of BINOL: A Unified Strategy for Arylation of BINOL
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A double-fold ortho and remote C-H borylation of BINOL is described. The proposed mechanisms involved electrostatically and sterically directed ortho and remote C-H activation processes, respectively. While B2eg2 (eg = ethylene glyco
- Bisht, Ranjana,Chaturvedi, Jagriti,Pandey, Gajanan,Chattopadhyay, Buddhadeb
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supporting information
p. 6476 - 6480
(2019/08/20)
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- Efficient synthesis of 3,3'-diaryl binaphthol through a one-step method
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The invention relates to a class of catalysis reactions of binaphthol and halogenated aromatic hydrocarbons, particularly to efficient preparation of 3,3'-diaryl binaphthol and 3-Bulkyaryl binaphtholthrough a one-step method, and belongs to the technical field of asymmetric catalysis. A purpose of the present invention is to provide a simple and practical method for preparing 3,3'-diaryl binaphthol through a one-step reaction of inexpensive BINOL and a brominated aromatic hydrocarbon reagent, and is further to provide a simple and rapid method for conveniently preparing 3-aryl binaphthol withhigh steric hindrance.
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Paragraph 0042-0044
(2018/07/30)
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- Catalytic Enantioselective Nazarov Cyclization
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A detailed account of an asymmetric Nazarov cyclization that leads to α-hydroxycyclopentenones bearing either vicinal, all-carbon quaternary centers, or vicinal quaternary and tertiary centers is given. The all-aliphatic examples represent the greatest challenge, as the dienone starting materials are not activated toward cyclization by an aryl group. The rational design and optimization of the substrates in parallel with optimization of the chiral Br?nsted acid catalyst is also described, as well as a series of diastereoselective transformations of a fully substituted cyclopentenone product.
- Jolit, Anais,Dickinson, Cody F.,Kitamura, Kei,Walleser, Patrick M.,Yap, Glenn P. A.,Tius, Marcus A.
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supporting information
p. 6067 - 6076
(2017/11/14)
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- Expedient BINOL derivative arylations
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A dramatic improvement of our previous methodology based on a Suzuki-Miyaura cross-coupling to access 3,3′-disubstituted H8-BINOLs using microwave heating is reported herein. These new conditions represent a large gain in term of atom-economy, reaction time, catalyst loading, and excess of reagents employed.
- Albini, Mathieu,Taillier, Catherine,Dalla, Vincent,Blanchet, Jér?me,Rouden, Jacques
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p. 6420 - 6422
(2014/12/10)
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