1243475-87-7Relevant articles and documents
VISUAL CYCLE MODULATORS
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Paragraph 00141, (2018/09/19)
A method of treating an ocular disorder in a subject in need thereof includes administering to the subject a therapeutically effective amount of a retinal sequestering compound of formula (I).
Rational tuning of visual cycle modulator pharmacodynamics
Kiser, Philip D.,Zhang, Jianye,Palczewski, Krzysztof,Badiee, Mohsen,Tochtrop, Gregory P.,Peachey, Neal S.,Kinoshita, Junzo
, p. 131 - 145 (2017/06/29)
Modulators of the visual cycle have been developed for treatment of various retinal disorders. These agents were designed to inhibit retinoid isomerase [retinal pigment epithelium-specific 65 kDa protein (RPE65)], the rate-limiting enzyme of the visual cy
Ruthenium(II)-catalyzed protocol for preparation of diverse α,β- and β,β-Dihaloenones from diazodicarbonyls
Magar, Krishna Bahadur Somai,Lee, Yong Rok
, p. 3422 - 3432 (2015/02/02)
Efficient one-step syntheses of α,β- and β,β-dihaloenones were achieved by ruthenium(II)- catalyzed reactions between cyclic or acyclic diazodicarbonyl compounds and oxalyl chloride or oxalyl bromide in moderate to good yields. This methodology offers sev