1244652-16-1

Basic information

• Product Name: 2,2,2-Trifluoro-N-(3-fluoro-2-iodo-phenyl)-acetaMide
• Synonyms: 2,2,2-Trifluoro-N-(3-fluoro-2-iodo-phenyl)-acetaMide
• CAS NO: 1244652-16-1
• Molecular Formula: C₈H₄F₄INO
• Molecular Weight: 333.0215428
• EINECS: -0
• Mol File: 1244652-16-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,2,2-Trifluoro-N-(3-fluoro-2-iodo-phenyl)-acetaMide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-Trifluoro-N-(3-fluoro-2-iodo-phenyl)-acetaMide(1244652-16-1)
• EPA Substance Registry System: 2,2,2-Trifluoro-N-(3-fluoro-2-iodo-phenyl)-acetaMide(1244652-16-1)

Safety Data

• Hazardous Substances Data: 1244652-16-1(Hazardous Substances Data)

Usage

Physical state

White solid

Molecular weight

261.17 g/mol

Uses

Intermediate in the synthesis of pharmaceuticals and agrochemicals, potential applications in materials science and organic chemistry

Safety precautions

Can cause skin, eye, and respiratory irritation; should be handled with care and stored in a cool, dry, well-ventilated area away from incompatible chemicals and sources of heat or ignition.

Upstream product

• 372-19-0 meta-fluoroaniline 
• 35980-21-3 2,2,2-trifluoro-N-(3-fluorophenyl)acetamide 

Downstream Products

• 1287791-84-7 2-butyl-4-fluoro-3-(2-nitrophenyl)-1H-indole 
• 1287791-83-6 4-fluoro-3-(2-nitrophenyl)-2-phenyl-1H-indole 
• 1287791-89-2 3-(4-fluoro-2-(4-methoxyphenyl)-1H-indol-3-yl)benzonitrile 
• 1287791-86-9 4-fluoro-2-hexyl-3-(4-methoxy-3-methylphenyl)-1H-indole 
• 1287791-90-5 2-(4-fluoro-2-hexyl-1H-indol-3-yl)benzonitrile 
• 1287791-85-8 4-fluoro-3-(3-methoxyphenyl)-2-phenyl-1H-indole 
• 1287791-88-1 2-cyclohexenyl-4-fluoro-3-(4-nitrophenyl)-1H-indole 
• 706752-99-0 3-fluoro-2-iodoaniline 
• 1287791-87-0 3-(4-fluoro-2-(thiophen-3-yl)-1H-indol-3-yl)benzonitrile 
• 1287791-91-6 4-fluoro-3-(3-methoxyphenyl)-2-thiophen-3-yl-1H-indole 

Relevant articles and documents

SULFONYL-SUBSTITUTED BICYCLIC COMPOUND WHICH ACTS AS ROR INHIBITOR

Provided is a sulfonyl-substituted bicyclic compound (A) which acts as a RORγ inhibitor, said compound has good RORγ inhibitory activity and is expected to be used for treating diseases mediated by a RORγ receptor in mammals.

Approaches to the synthesis of 2,3-dihaloanilines. Useful precursors of 4-functionalized-1 H-indoles

2,3-Dihaloanilines have been proved as useful starting materials for synthesizing 4-halo-1H-indoles. Subsequent or in situ functionalization of the prepared haloindoles allows the access to a wide variety of 2,4- or 2,3,4-regioselectively functionalized indoles in good overall yields. As no efficient synthetic routes to 2,3-dihaloanilines have been described in the literature, different approaches to the preparation of these 1,2,3-functionalized aromatic precursors are now presented. The most general one involves a Smiles rearrangement from the corresponding 2,3-dihalophenols and allows the preparation of 2,3-dihaloanilides in a straightforward and synthetically useful manner.

Synthesis of 4-functionalized-1H-indoles from 2,3-dihalophenols

A new synthesis of 4-halo-1H-indoles has been developed from easily available 2,3-dihalophenol derivatives. The key steps are Smiles rearrangement and a one-pot or stepwise Sonogashira coupling/NaOH-mediated cyclization. Subsequent functionalization allows access to a wide variety of 2,4- or 2,3,4-regioselectively functionalized indoles.