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1245526-82-2

Glucocorticoid receptor agonist is a class of chemicals that bind to and activate the glucocorticoid receptor, a type of nuclear receptor that plays a key role in regulating the body's response to stress and inflammation. When activated, these receptors can modulate gene expression, leading to anti-inflammatory and immunosuppressive effects.
Used in Pharmaceutical Industry:
Glucocorticoid receptor agonist is used as a therapeutic agent for the treatment of inflammatory and autoimmune conditions such as asthma, rheumatoid arthritis, and allergic reactions. By binding to the glucocorticoid receptor, these agonists help to reduce inflammation and the body's immune response, providing relief from symptoms associated with these conditions.
Used in Anti-Inflammatory Applications:
Glucocorticoid receptor agonist is used as an anti-inflammatory agent to alleviate symptoms caused by excessive inflammation in various conditions. The activation of the glucocorticoid receptor by these agonists leads to the modulation of gene expression, resulting in the suppression of pro-inflammatory cytokines and mediators, thus reducing inflammation.
Used in Immunosuppressive Applications:
Glucocorticoid receptor agonist is used as an immunosuppressive agent to dampen the body's immune response in autoimmune conditions. The activation of the glucocorticoid receptor by these agonists helps to suppress the overactive immune system, reducing the severity of autoimmune diseases and improving the quality of life for affected individuals.

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  • 1245526-82-2 Structure

  • Basic information

    1. Product Name: Glucocorticoid receptor agonist
    2. Synonyms: 1H-Pyrrolo[2,3-c]pyridine-2-ethanol, α-[2-(5-fluoro-2-hydroxyphenyl)-2-Methylpropyl]-α-(trifluoroMethyl)-, (αR)-;(ALPHAR)-ALPHA-[2-(5-FLUORO-2-HYDROXYPHENYL)-2-METHYLPROPYL]-ALPHA-(TRIFLUOROMETHYL)-1H-PYRROLO[2,3-C]PYRIDINE-2-ETHANOL;Glucocorticoid receptor agonist;alpha-[2-(5-Fluoro-2-hydroxyphenyl)-2-methylpropyl]-alpha-(trifluoromethyl)-(alphaR)-1H-pyrrolo[2,3-c]pyridine-2-ethanol
    3. CAS NO:1245526-82-2
    4. Molecular Formula: C20H20F4N2O2
    5. Molecular Weight: 396.3786128
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1245526-82-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 563.1±50.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.373
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 10.16±0.43(Predicted)
    10. CAS DataBase Reference: Glucocorticoid receptor agonist(CAS DataBase Reference)
    11. NIST Chemistry Reference: Glucocorticoid receptor agonist(1245526-82-2)
    12. EPA Substance Registry System: Glucocorticoid receptor agonist(1245526-82-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1245526-82-2(Hazardous Substances Data)

1245526-82-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1245526-82-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,5,5,2 and 6 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1245526-82:
(9*1)+(8*2)+(7*4)+(6*5)+(5*5)+(4*2)+(3*6)+(2*8)+(1*2)=152
152 % 10 = 2
So 1245526-82-2 is a valid CAS Registry Number.

1245526-82-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-fluoro-2-[(4R)-5,5,5-trifluoro-4-hydroxy-2-methyl-4-(1H-pyrrolo[2,3-c]pyridin-2-ylmethyl)pentan-2-yl]phenol

1.2 Other means of identification

Product number -
Other names Glucocorticoid receptor agonist

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1245526-82-2 SDS

1245526-82-2Upstream product

1245526-82-2Downstream Products

1245526-82-2Relevant articles and documents

Nonsteroidal dissociated glucocorticoid agonists containing azaindoles as steroid A-ring mimetics

Riether, Doris,Harcken, Christian,Razavi, Hossein,Kuzmich, Daniel,Gilmore, Thomas,Bentzien, J?rg,Pack, Edward J.,Souza, Donald,Nelson, Richard M.,Kukulka, Alison,Fadra, Tazmeen N.,Zuvela-Jelaska, Ljiljana,Pelletier, Josephine,Dinallo, Roger,Panzenbeck, Mark,Torcellini, Carol,Nabozny, Gerald H.,Thomson, David S.

experimental part, p. 6681 - 6698 (2010/12/19)

Syntheses and structure-activity relationships (SAR) of nonsteroidal glucocorticoid receptor (GR) agonists are described. These compounds contain azaindole moieties as A-ring mimetics and display various degrees of in vitro dissociation between gene trans

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