124576-25-6Relevant articles and documents
Aromatic lipoxin A4 and lipoxin B4 analogues display potent biological activities
O'Sullivan, Timothy P.,Vallin, Karl S. A.,Shah, Syed Tasadaque Ali,Fakhry, Jér?me,Maderna, Paola,Scannell, Michael,Sampaio, Andre L. F.,Perretti, Mauro,Godson, Catherine,Guiry, Patrick J.
, p. 5894 - 5902 (2007)
Lipoxins are a group of biologically active eicosanoids typically formed by transcellular lipoxygenase activity. Lipoxin A4 (LXA4) and Lipoxin B4 (LXB4) biosynthesis has been detected in a variety of inflammator
Furyl, phenylene, and thienyl leukotriene B4 analogues
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, (2008/06/13)
This invention relates to a compound of the formula: STR1 or a pharmaceutically acceptable salt thereof wherein X is oxygen, sulfur, or --CH=CH--; wherein Z is OR1 or --NR4 R5 ; wherein R1 is hydrogen, lower alkyl, or a pharmaceutically acceptable cation; wherein R2 is H, --CH3 or --C2 H5 ; wherein R3 is OH, H or =O; wherein R4 and R5 may independently be hydrogen, or lower alkyl having 1-6 carbon atoms, or R4 and R5 may act together with N to form a cyclic amide of the formula: STR2 wherein n is an integer from 4-5; and m is an integer from 0-4. More particularly, this invention relates to compounds of the above formula which have utility as LTB4 antagonists.