- Polyfluoroaralkyl amines. Further studies on the reactivity of 4,5,6,7-tetrafluoroindole
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4,5,6,7-tetrafluoroindole 1 undergoes electrophilic formylation and aminoalkylation at C-3 to give compounds that can be readily converted to a variety of products, including the skatole, tryptamine, and tryptophan. 1 reacts with ethyl diazoacetate to yield 4,5,6,7-tetrafluoroethyl-3-indole acetate.The Grignard reagent of 1 offers a direct route to the versatile substituted acetonitrile 10 via C-3 alkylation with chloroacetonitrile.Key words: tetrafluoroindole, tetrafluorotryptamine, tetrafluoroindolyl magnesium bromide, tetrafluorotryptophan.
- Filler, Robert,Woods, Sarah M.,White, William L.
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p. 1837 - 1841
(2007/10/02)
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