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2-Propionyl-4-bromoaniline is a chemical compound with the molecular formula C10H11BrNO. It is a yellow crystalline solid that is used in the pharmaceutical and chemical industries. As an aniline derivative, it contains a benzene ring with an amino group (-NH2) attached to it. The presence of a propionyl group (-C3H7O) and a bromine atom in its structure gives it unique properties and potential applications.

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  • 124623-15-0 Structure
  • Basic information

    1. Product Name: 2-propionyl-4-bromoaniline
    2. Synonyms: 2-propionyl-4-bromoaniline;1-(2-amino-5-bromophenyl)propan-1-one
    3. CAS NO:124623-15-0
    4. Molecular Formula: C9H10BrNO
    5. Molecular Weight: 228.088
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 124623-15-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-propionyl-4-bromoaniline(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-propionyl-4-bromoaniline(124623-15-0)
    11. EPA Substance Registry System: 2-propionyl-4-bromoaniline(124623-15-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 124623-15-0(Hazardous Substances Data)

124623-15-0 Usage

Uses

Used in Pharmaceutical Industry:
2-Propionyl-4-bromoaniline is used as an intermediate in the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs and medications.
Used in Chemical Industry:
2-Propionyl-4-bromoaniline is also used in the chemical industry for the synthesis of dyes and other organic compounds. Its versatility in chemical reactions makes it a valuable asset in the creation of a wide range of products.
Used in Research and Development:
Due to its unique properties, 2-Propionyl-4-bromoaniline is utilized in research and development for exploring new chemical reactions and applications. It can be a starting point for creating new compounds with potential uses in various industries.
It is important to handle and store 2-Propionyl-4-bromoaniline with proper safety measures, as it may be harmful if ingested, inhaled, or if it comes into contact with the skin.

Check Digit Verification of cas no

The CAS Registry Mumber 124623-15-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,4,6,2 and 3 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 124623-15:
(8*1)+(7*2)+(6*4)+(5*6)+(4*2)+(3*3)+(2*1)+(1*5)=100
100 % 10 = 0
So 124623-15-0 is a valid CAS Registry Number.

124623-15-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(2-amino-5-bromophenyl)propan-1-one

1.2 Other means of identification

Product number -
Other names Ethyl-5-brom-2-aminophenyl-keton

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:124623-15-0 SDS

124623-15-0Relevant articles and documents

Design of new reaction conditions for the Sugasawa reaction based on mechanistic insights

Prasad, Kapa,Lee, George T.,Chaudhary, Apurva,Girgis, Michael J.,Streemke, James W.,Repic, Oljan

, p. 723 - 732 (2003)

A process to prepare 2-propionyl-4-bromoaniline by ortho acylation of 4-bromoaniline under Sugasawa conditions was developed. Upon scale-up in a pilot plant, the process gave lower yields than in the laboratory in four out of five plant runs. Analysis of

1,2,4-TRIAZINE-3-AMINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF IN MEDICINE

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Paragraph 0287; 0288, (2019/11/28)

The present invention relates to a 1,2,4-triazine-3-amine derivative, a preparation therefor, and use thereof in medicine. Specifically, the present invention relates to a 1,2,4-triazine-3-amine derivative as represented by general formula (I), a preparation method therefor, a pharmaceutical composition comprising the derivative, and use thereof as a therapeutic agent, in particular as an A2a receptor antagonist, and use thereof in the preparation of a medicament for treating a condition or disorder that is ameliorated by means of inhibition of the A2a receptor, each substituent in general formula (I) being same as defined in the description.

Catalyst-free geminal aminofluorination of ortho-sulfonamide-tethered alkylidenecyclopropanes via a Wagner-Meerwein rearrangement

Fan, Xing,Wang, Qiang,Wei, Yin,Shi, Min

supporting information, p. 10503 - 10506 (2018/09/21)

A catalyst-free intramolecular geminal aminofluorination of ortho-sulfonamide-tethered alkylidenecyclopropanes has been developed. The reaction proceeded through two SET processes with Selectfluor to give a fluorinated cyclopropylcarbinyl cation and a further Wagner-Meerwein rearrangement to generate a cyclobutyl carbocation, which undergoes intramolecular nucleophilic capture by amide to forge fluorinated cyclobuta[b]indoline derivatives. A polycyclic multi-fluorinated byproduct was also formed through a Ritter-type reaction in some cases.

QUINAZOLINE-BASED KINASE INHIBITORS

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Page/Page column 71, (2016/04/26)

The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.

1,5-Dihydro-benzo[e][1,4]oxazepin-2(1H)-ones containing a 7-(5′-cyanopyrrol-2-yl) group as nonsteroidal progesterone receptor modulators

Kern, Jeffrey C.,Terefenko, Eugene A.,Fensome, Andrew,Unwalla, Ray,Wrobel, Jay,Cohen, Jeffrey,Zhu, Yuan,Berrodin, Thomas J.,Yudt, Matthew R.,Winneker, Richard C.,Zhang, Zhiming,Zhang, Puwen

scheme or table, p. 5015 - 5017 (2009/05/30)

A series of novel 7-(5′-cyanopyrrol-2-yl) substituted benzo[1,4]oxazepin-2-ones were prepared and tested for their progesterone receptor (PR) agonist or antagonist activity in the alkaline phosphatase assay using the human T47D breast carcinoma cell line.

Synthesis and antitumor activity of 20(S)-camptothecin derivatives. A-ring-substituted 7-ethylcamptothecins and their E-ring-modified water-soluble derivatives

Yaegashi,Sawada,Nagata,Furuta,Yokokura,Miyasaka

, p. 2518 - 2525 (2007/10/02)

Twenty-six novel A-ring-modified 7-ethylcamptothecins (6) were synthesized by Friedlander's condensation of the chiral tricyclic ketone (5) with aminopropiophenones (4). The compounds substituted with fluorine at the 11 position showed strong cytotoxicity

Camptothecin derivatives

-

, (2008/06/13)

New campotothecin derivatives and a process for preparing same are disclosed, which are represented by the general formula: STR1 wherein R1 represents a lower alkyl group, R2 represents a hydrogen atom or an amino, hydroxyl, lower acylamino or lower alkoxy group, R3 represents a hydrogen or halogen atom or a lower alkyl, hydroxyl, lower alkoxy, nitro, amino, cyano or di(lower alkyl)amino group, R4 represents a hydrogen or halogen atom or a lower alkyl, hydroxyl, lower alkoxy, lower alkylthio, amino, cyano or di(lower alkyl)amino group, and R5 represents a hydrogen or halogen atom or a hydroxyl or lower alkoxy group, with the proviso that all of the R2, R3, R4 and R5 substituents should not be a hydrogen atom and also that if any one of the R2, R3, R4 and R5 is a hydroxyl or lower alkoxy group, all of the other three substituents should not be a hydrogen atom.

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