cas 1246535-95-4, 5-(9-isopropyl-2-Morpholino-9H-purin-6-yl)pyriMidin-2-aMine | Articles data ｜lookchem

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1246535-95-4

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As an inhibitor pyrimidinecarboxylic substd. hydroxyaminopurine compd. serinekinase
PROBLEM TO BE SOLVED: To provide a pyrimidine substituted purine compound which can be used as a kinase inhibitor in a treatment of serine/threonine protein kinase related disorders/conditions, for example cancer, pre-cancer conditions or hyperplasia, autoimmune or inflammatory diseases or diseases caused by excessive angiogenesis.SOLUTION: There are provided 5-(9-isopropyl-8-methyl-2-morpholine-4-yl-9H-purine-6-yl)-pyrimidine-2-yl amine, preparation method thereof, and pharmaceutical compositions containing the compound.
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Paragraph 0080

(2016/12/16)

PYRIMIDINE SUBSTITUTED PURINE COMPOUNDS AS KINASE (S) INHIBITORS
The present invention relates to a purine compound useful as a kinase inhibitor. The compound has the structure (I) or a pharmaceutically acceptable salt thereof
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Page/Page column 8

(2012/06/16)

8-SUBSTITUTED-2-MORPHOLINO PURINES FOR USE AS PI3K AND/OR MTOR INHIBITORS IN THE TREATMENT OF PROLIFERATIVE DISORDERS
The present invention relates to purine compounds of formula (I): that are useful as kinase inhibitors. More particularly, the present invention relates to purine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative disorders including tumours and cancers as well as other disorders or conditions related to or associated with mTOR kinases.
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Page/Page column 76-77

(2010/11/03)

PYRIMIDINE SUBSTITUTED PURINE COMPOUNDS AS KINASE (S) INHIBITORS
The present invention relates to a purine compound useful as a kinase inhibitor. The compound has the structure (I) or a pharmaceutically acceptable salt thereof
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Page/Page column 20

(2010/11/03)

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Chemical Properties

Boiling Point: 669.3±65.0 °C(Predicted)
Density: 1.52±0.1 g/cm3(Predicted)
PKA: 3.94±0.10(Predicted)
PSA: 107.87000
LogP: 1.92920

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