A Synthesis of 1H-Indazoles via a Cu(OAc)2-Catalyzed N-N Bond Formation
A facile synthesis of 1H-indazoles featuring a Cu(OAc)2-catalyzed N-N bond formation using oxygen as the terminal oxidant is described. The reaction of readily available 2-aminobenzonitriles with various organometallic reagents led to o-aminoar
Chen, Cheng-Yi,Tang, Guangrong,He, Fengxian,Wang, Zhaobin,Jing, Hailin,Faessler, Roger
supporting information
p. 1690 - 1693
(2016/04/26)
Synthesis of N-arylindazoles and benzimidazoles from a common intermediate
A variety of N-aryl-1H-indazoles and benzimidazoles were synthesized from common arylamino oximes in good to excellent yields. The product selectivity depends upon the base used in the reaction, as triethylamine promoted the formation of benzimidazoles, whereas 2-aminopyridine promoted the formation of N-arylindazoles. This method is valuable to the synthetic community because both indazoles and benzimidazoles are prevalent in pharmaceuticals.
Wray, Brenda C.,Stambuli, James P.
supporting information; experimental part
p. 4576 - 4579
(2010/11/20)
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