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2-BROMO-5-CHLOROBENZONITRILE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 57381-37-0 Structure
  • Basic information

    1. Product Name: 2-BROMO-5-CHLOROBENZONITRILE
    2. Synonyms: 2-BROMO-5-CHLOROBENZONITRILE;2-Bromo-5-chlorobenzonitile
    3. CAS NO:57381-37-0
    4. Molecular Formula: C7H3BrClN
    5. Molecular Weight: 216.46
    6. EINECS: 200-258-5
    7. Product Categories: N/A
    8. Mol File: 57381-37-0.mol
  • Chemical Properties

    1. Melting Point: 138.8-139.2°C
    2. Boiling Point: 271.64 °C at 760 mmHg
    3. Flash Point: 118.084 °C
    4. Appearance: /
    5. Density: 1.74 g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: Sealed in dry,Room Temperature
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-BROMO-5-CHLOROBENZONITRILE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-BROMO-5-CHLOROBENZONITRILE(57381-37-0)
    11. EPA Substance Registry System: 2-BROMO-5-CHLOROBENZONITRILE(57381-37-0)
  • Safety Data

    1. Hazard Codes: Xn
    2. Statements: 22
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 57381-37-0(Hazardous Substances Data)

57381-37-0 Usage

Chemical Properties

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Check Digit Verification of cas no

The CAS Registry Mumber 57381-37-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,3,8 and 1 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 57381-37:
(7*5)+(6*7)+(5*3)+(4*8)+(3*1)+(2*3)+(1*7)=140
140 % 10 = 0
So 57381-37-0 is a valid CAS Registry Number.

57381-37-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Bromo-5-chlorobenzonitrile

1.2 Other means of identification

Product number -
Other names 2-BROMO-5-CHLOROBENZONITRILE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:57381-37-0 SDS

57381-37-0Relevant articles and documents

Selective synthesis of benzo[4,5]imidazo[2,1-a]isoquinolines via copper-catalyzed tandem annulation of alkynylbenzonitriles with 2-Iodoanilines

Liu, Xiaodong,Deng, Guobo,Liang, Yun

, p. 2844 - 2847 (2018/06/18)

An efficient copper-catalyzed cascade cyclization reaction for selectively synthesizing a variety of benzo[4,5]imidazo[2,1-a]isoquinoline derivatives has been developed. The reaction features the formation of three different C–N bonds in sequence. In the

A radical cyclization cascade of 2-alkynylbenzonitriles with sodium arylsulfinates

Zhou, Bang,Chen, Wenqi,Yang, Yuzhong,Yang, Yuan,Deng, Guobo,Liang, Yun

, p. 7959 - 7963 (2018/11/21)

A convenient radical cyclization cascade procedure for the construction of sulfonated indenones from 2-alkynylbenzonitriles and sodium arylsulfinates has been explored under mild reaction conditions. The present methodology offers a low-cost and operationally straightforward approach to synthesizing various sulfonated indenones in moderate to good yields by simple use of cheap sodium persulfate as an oxidant and environmentally benign water as a co-solvent.

Structure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5

Zhang, Peng,Zou, Mu-Fa,Rodriguez, Alice L.,Jeffrey Conn,Newman, Amy Hauck

scheme or table, p. 3026 - 3035 (2010/07/06)

The metabotropic glutamate receptor subtype 5 (mGluR5) has been implicated in numerous neuropsychiatric disorders including addiction. We have discovered that the rigid diaryl alkyne template, derived from the potent and selective noncompetitive mGluR5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP), can serve to guide the design of novel quinoline analogues and pharmacophore optimization has resulted in potent mGluR5 noncompetitive antagonists (EC50 range 60-100 nM) in the quinoline series.

Direct N-acetyl enamine formation: Lithium bromide mediated addition of methyllithium to nitriles

Savarin, Cecile G.,Boice, Genevieve N.,Murry, Jerry A.,Corley, Edward,DiMichele, Lisa,Hughes, Dave

, p. 3903 - 3906 (2007/10/03)

An improved protocol for N-acetyl enamine formation is disclosed which involves LiBr-mediated addition of MeLi to substituted nitriles. The resulting enamides are isolated in high yields and excellent purity which permits subsequent hydrogenation at very

An efficient synthesis of a highly functionalized 4-arylpiperidine

Boice, Geneviève N.,Savarin, Cécile G.,Murry, Jerry A.,Conrad, Karen,Matty, Louis,Corley, Edward G.,Smitrovich, Jacqueline H.,Hughes, Dave

, p. 11367 - 11374 (2007/10/03)

In this manuscript, an efficient synthesis of a functionalized 4-arylpiperidine is disclosed. Several synthetic approaches towards formation of the key aryl-piperidine sp3 carbon-carbon bond are discussed, including a scalable route to the piperidine via

Process and intermediates for the preparation of 4-aryl piperidines

-

Page 11, (2010/02/08)

A novel process is provided for the preparation of 4-aryl piperidines, and the useful intermediates obtained therein. These compounds are intermediates for the synthesis of melanocortin-4 receptor (MC-4R), which are useful for the treatment of disorders such as obesity, diabetes, male sexual dysfunction, and female sexual dysfunction.

Angiotensin II antagonizers which are condensed pyridine derivatives

-

, (2008/06/13)

The invention concerns pharmaceutically useful novel compounds of the formula I, in which R1, R2, R3, R4, R5, R6, R7, X and Z have the various meanings defined herein, and their non-toxic salts, and pharmaceutical compositions containing them. The novel compounds are of value in treating conditions such as hypertension and congestive heart failure. The invention further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment.

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