124688-07-9

Basic information

• Product Name: 2,3-DIHYDRO-2,2-DIMETHYL-6-METHOXY-1H-INDEN-1-ONE
• Synonyms: 2,3-DIHYDRO-2,2-DIMETHYL-6-METHOXY-1H-INDEN-1-ONE
• CAS NO: 124688-07-9
• Molecular Formula: C12H14O2
• Molecular Weight: 190.24
• Mol File: 124688-07-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,3-DIHYDRO-2,2-DIMETHYL-6-METHOXY-1H-INDEN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIHYDRO-2,2-DIMETHYL-6-METHOXY-1H-INDEN-1-ONE(124688-07-9)
• EPA Substance Registry System: 2,3-DIHYDRO-2,2-DIMETHYL-6-METHOXY-1H-INDEN-1-ONE(124688-07-9)

Safety Data

• Hazardous Substances Data: 124688-07-9(Hazardous Substances Data)

Usage

Bicyclic ketone

It is a bicyclic ketone, meaning it has a structure composed of two interconnected rings, with one of the rings containing a carbonyl group (C=O).

Methoxy group

A methoxy group (-OCH3) is attached to the six-membered ring in the compound, which contributes to its aromatic properties.

Sweet, floral, and woody aroma

2,3-DIHYDRO-2,2-DIMETHYL-6-METHOXY-1H-INDEN-1-ONE is known for imparting a sweet, floral, and woody aroma, making it a popular choice in the fragrance and flavor industry.

Common uses in perfumes and colognes

The compound is widely used in the production of perfumes, colognes, and other scented products due to its pleasant aroma.

Potential applications in pharmaceuticals

2,3-DIHYDRO-2,2-DIMETHYL-6-METHOXY-1H-INDEN-1-ONE may have potential applications in the pharmaceutical industry, although its specific uses and health effects are not yet fully understood.

Proper handling and disposal

Due to the potential health effects and environmental impact of this chemical compound, it is important to follow proper handling and disposal procedures in accordance with local regulations.

Upstream product

• 1355253-97-2 C₁₅H₂₄O₂Si 
• 6026-75-1 1-(3-methoxyphenyl)-2-methyl-propan-1-one 
• 13623-25-1 6-methoxy-2,3-dihydro-1H-inden-1-one 
• 74-88-4 methyl iodide 

Downstream Products

• 165072-41-3 6-methoxy-2,2-dimethyl-2,3-dihydro-1H-indene-1-ol 

Relevant articles and documents

Silylative Kinetic Resolution of Racemic 2,2-Dialkyl 5- and 6-Membered Cyclic Benzylic Alcohol Derivatives Catalyzed by Chiral Guanidine, (R)-N-Methylbenzoguanidine

Efficient silylative kinetic resolution of racemic 2,2-dialkyl 5- and 6-membered cyclic benzylic alcohols was achieved using diphenylmethylchlorosilane (Ph2MeSiCl) or phenyldimethylchlorosilane (PhMe2SiCl) as a silyl source catalyzed by chiral guanidine. The reaction could be applied to a broad range of 2,2-dialkyl 1-indanols with good s-values, irrespective of the electronic nature of the substituent on the aromatic ring of the substrates and the type of substituent at the C2-position. In addition, several 2,2-dimethyl 6-membered cyclic and heterocyclic alcohols could be adopted in the reaction. (Figure presented.).

A Chiral Electrophilic Selenium Catalyst for Highly Enantioselective Oxidative Cyclization

Chiral electrophilic selenium catalysts have been applied to catalytic asymmetric transformations of alkenes over the past two decades. However, highly enantioselective reactions with a broad substrate scope have not yet been developed. We report the first successful example of this reaction employing a catalyst based on a rigid indanol scaffold, which can be easily synthesized from a commercially available indanone. The reaction efficiently converts β,γ-unsaturated carboxylic acids into various enantioenriched γ-butenolides under mild conditions.

Synthesis of α-indanones via intramolecular direct arylation with cyclopropanol-derived homoenolates

A palladium-catalysed, tandem cyclopropanol rearrangement and direct arylation approach for the synthesis of 1-indanones is reported. The reaction is generally high yielding, uses oxygen as the terminal oxidant and tolerates a range of functional groups on the aryl ring.

RECEPTOR FUNCTION REGULATING AGENT

An agent for regulating 14273 receptor function, which is useful as a preventing or treating drug for diabetes mellitus, hyperlipidemia or the like, is provided. An agent for regulating 14273 receptor function comprising a compound containing an aromatic ring and a group capable of releasing a cation.

Benzocycloalkene compounds, their production and use

A compound of the formula wherein R1and R2are H, a hydrocarbon group or a heterocyclic group, or R1and R2are combinedly a spiro ring; R3is a hydrocarbon group, a substituted amino group, a substituted

The Photochemistry of Conformationally Rigid Benzylic Esters: 2,2-Dimethyl-1-indanyl Acetates and Pivalates

The photochemistry, in methanol, of substituted 2,2-dimethyl-1-indanyl acetates 9a-c and pivalates 10a-c has been studied.In agreement with previous studies on benzylic esters, the results show that the substituents change the yield of products derived from the ion pair.The mechanistic conclusion reached is that the substituents change the oxidation potential of the indanyl radicals and thus the rate constant of electron transfer for converting the radical pair to the ion pair.The results also reveal two other substituent effects.First, substituents can increase the overall efficiency of the photoreaction by enhancing homolytic cleavage.The second effect is conformational.In compounds where the bond that is cleaving is conformationally mobile, such as the C-O bond in benzylic esters, substituents on the ring can change the population of the reactive conformer and thus the overall efficiency of the reaction.For the indanyl acetate esters, the difference in excited-state reaction rate between the m- and p-methoxy substituted ester is 15:1.For the m- and p-methoxy substituted benzyl acetates, this difference in reaction rate is 48:1.The larger difference in reaction rate for the conformationally mobile benzylic esters is attributed to a higher population of the unreactive conformer for the p-methoxy substituted ester.

Method for producing 1-indanone derivatives

A method is provided for the production of 2,2-diorgano-1-indanones, e.g., 2,2-dimethyl-1-indanone, by reacting an alcohol which is the corresponding (diorganosubstitutedmethyl)phenyl(or substitutedphenyl)carbinol, e.g., 2-methyl-1-phenyl-1-propanol, with carbon monoxide in the presence of a Lewis acid catalyst, e.g., hydrogen fluoride, with any substituents on the phenyl group of the alcohol being hydroxy or organo. The foregoing reaction is preferably integrated with the preparation of the feed alcohol by reducing the corresponding (diorganosubstitutedmethyl)phenyl(or substitutedphenyl)ketone, e.g., isobutyrophenone, with a reducing agent containing available hydrogen, e.g., sodium borohydride, or with hydrogen gas in the presence of a hydrogenation catalyst.

W(CO)6-Mediated Desulfurdimerization of Dithioketals. Evidence for a Thione Intermediate

Upon treatment with W(CO)6, dithioketals undergo desulfurdimerization to give the corresponding dimeric olefins in good to excellent yields.The mechanism of this the newly discovered reaction has been investigated.Thioketones have been isolated from the reactions of highly crowded dithioketals.The mechanism for the formation of thioketones has been shown to occur via a new type of radical fragmentation process of dithiolane.Thermolysis of 2,2-dimethylindan-1-yl 2-thiophenoxyethyl sulfide in the presence of tert-butyl adamantane-1-peroxycarboxylate (a typical radical initiator) has been studied for comparison.Thioketones react with W(CO)6, giving dimeric olefins and/or undergoing carbene-like insertion reactions.