6-Methoxy-2,2-dimethyl-1-indanone

Base Information

• Chemical Name: 6-Methoxy-2,2-dimethyl-1-indanone
• CAS No.: 124688-07-9
• Molecular Formula: C₁₂H₁₄O₂
• Molecular Weight: 190.242
• DSSTox Substance ID: DTXSID80435270
• Wikidata: Q82250084
• Mol file: 124688-07-9.mol

Synonyms:124688-07-9;6-methoxy-2,2-dimethyl-3H-inden-1-one;6-methoxy-2,2-dimethyl-1-indanone;6-Methoxy-2,2-dimethyl-2,3-dihydro-1H-inden-1-one;2,3-DIHYDRO-2,2-DIMETHYL-6-METHOXY-1H-INDEN-1-ONE;SCHEMBL2351080;DTXSID80435270;NFXFFWSSQPGDOX-UHFFFAOYSA-N;AKOS006309047;BS-47115;E79779

Chemical Property of 6-Methoxy-2,2-dimethyl-1-indanone

Chemical Property:

• PSA: 26.30000
• LogP: 2.46020
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 190.099379685
• Heavy Atom Count: 14
• Complexity: 245

Purity/Quality:

99% ^*data from raw suppliers

2,3-Dihydro-2,2-dimethyl-6-methoxy-1h-inden-1-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(CC2=C(C1=O)C=C(C=C2)OC)C

Technology Process of 6-Methoxy-2,2-dimethyl-1-indanone

There total 5 articles about 6-Methoxy-2,2-dimethyl-1-indanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

6-methoxy-2,3-dihydro-1H-inden-1-one (13623-25-1) + methyl iodide (74-88-4) → 6-methoxy-2,2-dimethyl-1-indanone (124688-07-9)

Guidance literature:

In 1,2-dimethoxyethane; water;

Reference yield: 85.0%

→ 6-methoxy-2,2-dimethyl-1-indanone (124688-07-9)

Guidance literature:

Reference yield: 70.0%

C15H24O2Si (1355253-97-2) → 6-methoxy-2,2-dimethyl-1-indanone (124688-07-9)

Guidance literature:

C₁₅H₂₄O₂Si; With potassium acetate; palladium diacetate; In N,N-dimethyl acetamide; at 20 ℃; for 0.0833333h; Inert atmosphere;

With tetrabutyl ammonium fluoride; oxygen; In N,N-dimethyl acetamide; at 20 - 100 ℃;

DOI:10.1039/c2cc16758a

upstream raw materials:

6-methoxy-2,3-dihydro-1H-inden-1-one

methyl iodide

C₁₅H₂₄O₂Si

1-(3-methoxyphenyl)-2-methyl-propan-1-one

Downstream raw materials:

6-methoxy-2,2-dimethyl-2,3-dihydro-1H-indene-1-ol

Refernces

• 1、 Kawamata, Yu,Hashimoto, Takuya,Maruoka, Keiji. "A Chiral Electrophilic Selenium Catalyst for Highly Enantioselective Oxidative Cyclization". supporting information. p. 5206 - 5209. Retrieved 2016/05/19.
• 2、 -. "RECEPTOR FUNCTION REGULATING AGENT". Page/Page column 84. . Retrieved 2010/11/23.