- Preparation method and intermediate of halogenated aromatic hydrocarbon compound
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The invention discloses a preparation method and an intermediate of a halogenated aromatic hydrocarbon compound, wherein the preparation method has the advantages of simple and accessible raw materials, low reagent price, high yield and simple operation,
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- Preparation method of aromatic hydrocarbon compound
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The invention relates to a preparation method of an aromatic hydrocarbon compound, and particularly discloses a preparation method of a compound as shown in a formula I. The preparation method comprises the following step: in trifluoroacetic acid, under the action of triethylsilane, carrying out a reduction reaction as shown in the specification on a compound as shown in a formula II. The invention further discloses a preparation method of the compound 1, wherein the preparation method is simple in raw material, simple and convenient to operate, low in equipment requirement, small in environmental pollution, low in cost and very suitable for industrial production.
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- Synthesis method of alectinib hydrochloride intermediate 2-(4-ethyl-3-iodophenyl)-2-methylpropanoic acid
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The invention discloses a synthesis method of an alectinib hydrochloride intermediate 2-(4-ethyl-3-iodophenyl)-2-methylpropanoic acid. The method is characterized by comprising the following steps: reacting 4-ethyl acetophenone with a methyl Grignard reag
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Paragraph 0062-0064; 0068-0069; 0072; 0076-0077; 0080; 0084
(2020/12/29)
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- Method for synthesizing alecensa hydrochloride intermediate 2-(4-ethyl-3-iodophenyl)-2-methylpropanoic acid
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The invention discloses a method for synthesizing an alecensa hydrochloride intermediate 2-(4-ethyl-3-iodophenyl)-2-methylpropanoic acid. The method is characterized by comprising steps of carrying out Friedel-Crafts reaction on ethylbenzene and 3-halogen-2-methyl-1-propylene to obtain 1-halogn-2-(4-ethyl phenyl)-2-methylpropane; carrying out reaction on the 1-halogn-2-(4-ethyl phenyl)-2-methylpropane and magnesium to obtain 2-(4-ethyl phenyl)-2-methyl propyl magnesium halide; carrying out reaction on the 2-(4-ethyl phenyl)-2-methyl propyl magnesium halide and oxygen to obtain 2-(4-ethyl phenyl)-2-methyl-1-propyl alcohol; oxidizing the 2-(4-ethyl phenyl)-2-methyl-1-propyl alcohol, sodium hypochlorite and sodium chlorite by the aid of 2,2,6,6-tetramethyl piperidine oxide to obtain 2-(4-ethyl phenyl)-2-methylpropanoic acid; carrying out reaction on the 2-(4-ethyl phenyl)-2-methylpropanoic acid and iodine in the presence of oxidizing agents under acidic conditions to obtain the alecensa hydrochloride intermediate. 2-(4-ethyl-3-iodophenyl)-2-methylpropanoic acid. The 2,2,6,6-tetramethyl piperidine oxide is used as a catalyst. The method has the advantages that the method is easy and convenient to operate, high in yield, low in cost and little in pollution, raw materials for the alecensa hydrochloride intermediate 2-(4-ethyl-3-iodophenyl)-2-methylpropanoic acid are inexpensive and are easily available, and industrial production can be facilitated.
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Paragraph 0054; 0061-0062; 0065; 0072-0073; 0076; 0083-0084
(2019/04/02)
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- Preparation method of alectinib intermediate
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The invention discloses a preparation method of 2-(4-ethyl-3-iodine) phenyl-2-methyl propionic acid as an alectinib intermediate. According to the preparation method, the operation danger class and production cost are reduced by optimizing and improving a
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- A NOVEL PROCESS FOR THE PREPARATION OF AN INTERMEDIATE OF ALECTINIB
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The present invention provides a novel process for the preparation of 2-(4-Ethyl-3-iodophenyl)-2-methylpropanoic acid of Formula (I), (I) which is a key intermediate in the synthesis of Alectinib or its salt of Formula (II).
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Page/Page column 11
(2019/03/12)
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