1247119-83-0

Basic information

• Product Name: 2-(4-ethylphenyl)-2-Methylpropanoic acid
• Synonyms: 2-(4-ethylphenyl)-2-Methylpropanoic acid;2-(4-ethylphenyl)-2-Methylpropanoic acid-6;Alectinib Intermediates;8-{[(2S)-3,3-DIMETHYL-2-OXIRANYL]METHYL}-7-METHOXY-2H-CHROMEN-2-ONE;4-ethyl-α,α-dimethyl-Benzeneacetic acid;4-Ethyl-alpha,alpha-dimethylbenzeneacetic acid
• CAS NO: 1247119-83-0
• Molecular Formula: C12H16O2
• Molecular Weight: 192.25424
• Mol File: 1247119-83-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 302.8±11.0 °C(Predicted)
• Appearance: /
• Density: 1.047±0.06 g/cm3(Predicted)
• PKA: 4.48±0.10(Predicted)
• CAS DataBase Reference: 2-(4-ethylphenyl)-2-Methylpropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-ethylphenyl)-2-Methylpropanoic acid(1247119-83-0)
• EPA Substance Registry System: 2-(4-ethylphenyl)-2-Methylpropanoic acid(1247119-83-0)

Safety Data

• Hazardous Substances Data: 1247119-83-0(Hazardous Substances Data)

Usage

Uses

2-?(4-?Ethylphenyl)?-?2-?methylpropanoic Acid an intermediate of Alectinib (C183360), a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth.

Upstream product

• 826-55-1 2-methyl-2-phenylpropionic acid 
• 124-38-9 carbon dioxide 
• 103859-07-0 2-chloro-2-(4-ethylphenyl)propane 
• 937-30-4 4-ethylacetophenone 
• 857768-18-4 2-(4-acetyl-phenyl)-2-methyl-propionic acid 
• 57625-74-8 methyl 2-methyl-2-phenylpropionate 
• 85010-92-0 2-(4-ethylphenyl)-2-methyl-1-propanol 
• 91561-14-7 1-chloro-2-(4-ethylphenyl)-2-methylpropane 
• 14387-10-1 (4-ethyl-phenyl)-acetic acid 
• 1585-07-5 1-bromo-4-ethylbenzene 
• 36207-10-0 (4-Ethyl-phenyl)-acetic acid methyl ester 
• 74-88-4 methyl iodide 
• 698394-59-1 methyl 2-(4-ethylphenyl)-2-methyl-propanoate 
• 698394-60-4 2-bromo-1-(4-ethylphenyl)-2-methyl-propan-1-one 

Downstream Products

• 1256584-75-4 tert-butyl 6-cyano-2-[1-(4-ethyl-3-iodo-phenyl)-1-methyl-ethyl]-1H-indole-3-carboxylate 
• 1256580-46-7 C⁽²⁴⁸⁾H₅₄₀₂ 

Relevant articles and documents

Preparation method of aromatic hydrocarbon compound

The invention relates to a preparation method of an aromatic hydrocarbon compound, and particularly discloses a preparation method of a compound as shown in a formula I. The preparation method comprises the following step: in trifluoroacetic acid, under the action of triethylsilane, carrying out a reduction reaction as shown in the specification on a compound as shown in a formula II. The invention further discloses a preparation method of the compound 1, wherein the preparation method is simple in raw material, simple and convenient to operate, low in equipment requirement, small in environmental pollution, low in cost and very suitable for industrial production.

Preparation method and intermediate of halogenated aromatic hydrocarbon compound

The invention discloses a preparation method and an intermediate of a halogenated aromatic hydrocarbon compound, wherein the preparation method has the advantages of simple and accessible raw materials, low reagent price, high yield and simple operation,

Preparation method of alectinib intermediate

The invention discloses a preparation method of 2-(4-ethyl-3-iodine) phenyl-2-methyl propionic acid as an alectinib intermediate. According to the preparation method, the operation danger class and production cost are reduced by optimizing and improving a